DRL19_ARATH
ID DRL19_ARATH Reviewed; 898 AA.
AC Q9C8T9;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Putative disease resistance protein At1g63350;
GN OrderedLocusNames=At1g63350; ORFNames=F2K11.24, F9N12.3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Potential disease resistance protein. {ECO:0000250}.
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC022355; AAG52150.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34089.1; -; Genomic_DNA.
DR PIR; E96659; E96659.
DR RefSeq; NP_176524.1; NM_105014.2.
DR AlphaFoldDB; Q9C8T9; -.
DR SMR; Q9C8T9; -.
DR STRING; 3702.AT1G63350.1; -.
DR PaxDb; Q9C8T9; -.
DR PRIDE; Q9C8T9; -.
DR EnsemblPlants; AT1G63350.1; AT1G63350.1; AT1G63350.
DR GeneID; 842641; -.
DR Gramene; AT1G63350.1; AT1G63350.1; AT1G63350.
DR KEGG; ath:AT1G63350; -.
DR Araport; AT1G63350; -.
DR TAIR; locus:2031366; AT1G63350.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000427_4_0_1; -.
DR InParanoid; Q9C8T9; -.
DR OMA; CLKNLEC; -.
DR PhylomeDB; Q9C8T9; -.
DR PRO; PR:Q9C8T9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C8T9; baseline and differential.
DR Genevisible; Q9C8T9; AT.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW Plant defense; Reference proteome; Repeat.
FT CHAIN 1..898
FT /note="Putative disease resistance protein At1g63350"
FT /id="PRO_0000212751"
FT DOMAIN 137..440
FT /note="NB-ARC"
FT REPEAT 516..537
FT /note="LRR 1"
FT REPEAT 538..559
FT /note="LRR 2"
FT REPEAT 562..584
FT /note="LRR 3"
FT REPEAT 586..608
FT /note="LRR 4"
FT REPEAT 609..631
FT /note="LRR 5"
FT REPEAT 632..654
FT /note="LRR 6"
FT COILED 24..88
FT /evidence="ECO:0000255"
FT BINDING 179..186
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 898 AA; 102627 MW; 41736DFABEA27A69 CRC64;
MGISFSIPFD PCVNKVSQWL DMKVSYTHNL EKNLVALETT MEELKAKRDD LLRKLKREED
RGLQTLGEIK VWLNRVETIE SRVNDLLNAR NAELQRLCLC GFCSKSLTTS YRYGKSVFLK
LREVEKLERR VFEVISDQAS TSEVEEQQLQ PTIVGQETML DNAWNHLMED GVGIMGLYGM
GGVGKTTLLT QINNKFSKYM CGFDSVIWVV VSKEVNVENI LDEIAQKVHI SGEKWDTKYK
YQKGVYLYNF LRKMRFVLFL DDIWEKVNLV EIGVPFPTIK NKCKVVFTTR SLDVCTSMGV
EKPMEVQCLA DNDAYDLFQK KVGQITLGSD PEIRELSRVV AKKCCGLPLA LNVVSETMSC
KRTVQEWRHA IYVLNSYAAK FSGMDDKILP LLKYSYDSLK GEDVKMCLLY CALFPEDAKI
RKENLIEYWI CEEIIDGSEG IDKAENQGYE IIGSLVRASL LMEEVELDGA NIVCLHDVVR
EMALWIASDL GKQNEAFIVR ASVGLREILK VENWNVVRRM SLMKNNIAHL DGRLDCMELT
TLLLQSTHLE KISSEFFNSM PKLAVLDLSG NYYLSELPNG ISELVSLQYL NLSSTGIRHL
PKGLQELKKL IHLYLERTSQ LGSMVGISCL HNLKVLKLSG SSYAWDLDTV KELEALEHLE
VLTTTIDDCT LGTDQFLSSH RLMSCIRFLK ISNNSNRNRN SSRISLPVTM DRLQEFTIEH
CHTSEIKMGR ICSFSSLIEV NLSNCRRLRE LTFLMFAPNL KRLHVVSSNQ LEDIINKEKA
HDGEKSGIVP FPKLNELHLY NLRELKNIYW SPLPFPCLEK INVMGCPNLK KLPLDSKSGK
HGGNGLIITH REMEWITRVE WEDEATKTRF LANRSSFSSS LICFSNDLVS RDMNCFHL
