ID   DRL20_ARATH             Reviewed;         884 AA.
AC   Q9SH22;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Probable disease resistance protein At1g63360;
GN   OrderedLocusNames=At1g63360; ORFNames=F2K11.23, F9N12.2;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
CC   -!- FUNCTION: Probable disease resistance protein. {ECO:0000250}.
CC   -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC       pathogen recognition. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC       of disease resistance gene homologs;
CC       URL="http://niblrrs.ucdavis.edu";
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DR   EMBL; AC008047; AAF19701.1; -; Genomic_DNA.
DR   EMBL; AC022355; AAG52149.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE34090.1; -; Genomic_DNA.
DR   PIR; F96659; F96659.
DR   RefSeq; NP_176525.1; NM_105015.2.
DR   AlphaFoldDB; Q9SH22; -.
DR   SMR; Q9SH22; -.
DR   BioGRID; 27863; 2.
DR   IntAct; Q9SH22; 2.
DR   STRING; 3702.AT1G63360.1; -.
DR   PaxDb; Q9SH22; -.
DR   PRIDE; Q9SH22; -.
DR   ProteomicsDB; 224317; -.
DR   EnsemblPlants; AT1G63360.1; AT1G63360.1; AT1G63360.
DR   GeneID; 842642; -.
DR   Gramene; AT1G63360.1; AT1G63360.1; AT1G63360.
DR   KEGG; ath:AT1G63360; -.
DR   Araport; AT1G63360; -.
DR   TAIR; locus:2031356; AT1G63360.
DR   eggNOG; KOG4658; Eukaryota.
DR   HOGENOM; CLU_000427_4_0_1; -.
DR   InParanoid; Q9SH22; -.
DR   OMA; NCEEMEM; -.
DR   OrthoDB; 320361at2759; -.
DR   PhylomeDB; Q9SH22; -.
DR   PRO; PR:Q9SH22; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9SH22; baseline and differential.
DR   Genevisible; Q9SH22; AT.
DR   GO; GO:0005634; C:nucleus; HDA:TAIR.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.8.430; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; PTHR23155; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW   Plant defense; Reference proteome; Repeat.
FT   CHAIN           1..884
FT                   /note="Probable disease resistance protein At1g63360"
FT                   /id="PRO_0000212752"
FT   DOMAIN          136..440
FT                   /note="NB-ARC"
FT   REPEAT          569..591
FT                   /note="LRR 1"
FT   REPEAT          593..615
FT                   /note="LRR 2"
FT   REPEAT          616..638
FT                   /note="LRR 3"
FT   REPEAT          639..661
FT                   /note="LRR 4"
FT   COILED          20..70
FT                   /evidence="ECO:0000255"
FT   BINDING         179..186
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   884 AA;  101079 MW;  AD080B807DC0E139 CRC64;
     MGISFSIPFD PCVNKVSQWL DMKVSYTHNL EKNLAALEKT MKELKAKRDD LERRLKREEA
     RGLQRLSEFQ VWLDSVATVE DIIITLLRDR NVEIQRLCLC RFCSKSLTRS YRYGKSVFLR
     LREVEKLKGE VFGVITEQAS TSAFEERPLQ PTIVGQDTML DKAGKHLMED GVGIMGMYGM
     GGVGKTTLLT QLYNMFNKDK CGFDIGIWVV VSQEFHVEKV QDEIAQKLGL GGDEWTQKDK
     SQKGICLYNI LREKSFVLFL DDIWEKVDLA EIGVPDPRTK KGRKLAFTTR SQEVCARMGV
     EHPMEVQCLE ENVAFDLFQK KVGQTTLGSD PGIPQLARIV AKKCCGLPLA LNVIGETMSC
     KRTIQEWRHA IHVLNSYAAE FIGMEDKVLP LLKYSYDNLK GEQVKSSLLY CALYPEDAKI
     LKEDLIEHWI CEEIIDGSEG IEKAEDKGYE IIGCLVRASL LMEWDDGDGR RAVCMHDVVR
     EMALWIASEL GIQKEAFIVR AGVGVREIPK IKNWNVVRRM SLMENKIHHL VGSYECMELT
     TLLLGKREYG SIRSQLKTIS SEFFNCMPKL AVLDLSHNKS LFELPEEISN LVSLKYLNLL
     YTEISHLPKG IQELKKIIHL NLEYTRKLES ITGISSLHNL KVLKLFRSRL PWDLNTVKEL
     ETLEHLEILT TTIDPRAKQF LSSHRLLSHS RLLEIYGSSV SSLNRHLESL SVSTDKLREF
     QIKSCSISEI KMGGICNFLS LVDVNIFNCE GLRELTFLIF APKIRSLSVW HAKDLEDIIN
     EEKACEGEES GILPFPELNF LTLHDLPKLK KIYWRPLPFL CLEEINIREC PNLRKLPLDS
     TSGKQGENGC IIRNKDSRWF EGVKWADEAT KKRFLPSCQL ISLK