ID   DRL21_ARATH             Reviewed;        1424 AA.
AC   Q9LRR5;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Putative disease resistance protein At3g14460;
GN   OrderedLocusNames=At3g14460; ORFNames=MOA2.6;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT   features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:131-135(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
CC   -!- FUNCTION: Potential disease resistance protein. {ECO:0000250}.
CC   -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC       pathogen recognition. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC       of disease resistance gene homologs;
CC       URL="http://niblrrs.ucdavis.edu";
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DR   EMBL; AB028617; BAB01338.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE75529.1; -; Genomic_DNA.
DR   RefSeq; NP_188064.1; NM_112306.2.
DR   AlphaFoldDB; Q9LRR5; -.
DR   SMR; Q9LRR5; -.
DR   STRING; 3702.AT3G14460.1; -.
DR   PaxDb; Q9LRR5; -.
DR   PRIDE; Q9LRR5; -.
DR   EnsemblPlants; AT3G14460.1; AT3G14460.1; AT3G14460.
DR   GeneID; 820669; -.
DR   Gramene; AT3G14460.1; AT3G14460.1; AT3G14460.
DR   KEGG; ath:AT3G14460; -.
DR   Araport; AT3G14460; -.
DR   TAIR; locus:2091662; AT3G14460.
DR   eggNOG; KOG4658; Eukaryota.
DR   HOGENOM; CLU_000837_8_8_1; -.
DR   InParanoid; Q9LRR5; -.
DR   OMA; FCIESYQ; -.
DR   OrthoDB; 145902at2759; -.
DR   PhylomeDB; Q9LRR5; -.
DR   PRO; PR:Q9LRR5; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9LRR5; baseline and differential.
DR   Genevisible; Q9LRR5; AT.
DR   GO; GO:0004016; F:adenylate cyclase activity; IDA:TAIR.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IMP:TAIR.
DR   GO; GO:0050832; P:defense response to fungus; IMP:TAIR.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.8.430; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 3.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR041118; Rx_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; PTHR23155; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF18052; Rx_N; 1.
DR   SMART; SM00369; LRR_TYP; 3.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Leucine-rich repeat; Nucleotide-binding; Plant defense;
KW   Reference proteome; Repeat.
FT   CHAIN           1..1424
FT                   /note="Putative disease resistance protein At3g14460"
FT                   /id="PRO_0000212753"
FT   DOMAIN          152..454
FT                   /note="NB-ARC"
FT   REPEAT          498..523
FT                   /note="LRR 1"
FT   REPEAT          552..571
FT                   /note="LRR 2"
FT   REPEAT          572..595
FT                   /note="LRR 3"
FT   REPEAT          597..618
FT                   /note="LRR 4"
FT   REPEAT          620..641
FT                   /note="LRR 5"
FT   REPEAT          642..665
FT                   /note="LRR 6"
FT   REPEAT          806..830
FT                   /note="LRR 7"
FT   REPEAT          1090..1114
FT                   /note="LRR 8"
FT   REPEAT          1118..1139
FT                   /note="LRR 9"
FT   REPEAT          1238..1262
FT                   /note="LRR 10"
FT   REPEAT          1264..1286
FT                   /note="LRR 11"
FT   REPEAT          1310..1336
FT                   /note="LRR 12"
FT   REGION          911..977
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1050..1070
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        911..975
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         200..207
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1424 AA;  158907 MW;  D7178B8443AB3BA9 CRC64;
     MANSYLSSCA NVMVERINTS QELVELCKGK SSSALLKRLK VALVTANPVL ADADQRAEHV
     REVKHWLTGI KDAFFQAEDI LDELQTEALR RRVVAEAGGL GGLFQNLMAG REAIQKKIEP
     KMEKVVRLLE HHVKHIEVIG LKEYSETREP QWRQASRSRP DDLPQGRLVG RVEDKLALVN
     LLLSDDEISI GKPAVISVVG MPGVGKTTLT EIVFNDYRVT EHFEVKMWIS AGINFNVFTV
     TKAVLQDITS SAVNTEDLPS LQIQLKKTLS GKRFLLVLDD FWSESDSEWE SFQVAFTDAE
     EGSKIVLTTR SEIVSTVAKA EKIYQMKLMT NEECWELISR FAFGNISVGS INQELEGIGK
     RIAEQCKGLP LAARAIASHL RSKPNPDDWY AVSKNFSSYT NSILPVLKLS YDSLPPQLKR
     CFALCSIFPK GHVFDREELV LLWMAIDLLY QPRSSRRLED IGNDYLGDLV AQSFFQRLDI
     TMTSFVMHDL MNDLAKAVSG DFCFRLEDDN IPEIPSTTRH FSFSRSQCDA SVAFRSICGA
     EFLRTILPFN SPTSLESLQL TEKVLNPLLN ALSGLRILSL SHYQITNLPK SLKGLKLLRY
     LDLSSTKIKE LPEFVCTLCN LQTLLLSNCR DLTSLPKSIA ELINLRLLDL VGTPLVEMPP
     GIKKLRSLQK LSNFVIGRLS GAGLHELKEL SHLRGTLRIS ELQNVAFASE AKDAGLKRKP
     FLDGLILKWT VKGSGFVPGS FNALACDQKE VLRMLEPHPH LKTFCIESYQ GGAFPKWLGD
     SSFFGITSVT LSSCNLCISL PPVGQLPSLK YLSIEKFNIL QKVGLDFFFG ENNSRGVPFQ
     SLQILKFYGM PRWDEWICPE LEDGIFPCLQ KLIIQRCPSL RKKFPEGLPS STEVTISDCP
     LRAVSGGENS FRRSLTNIPE SPASIPSMSR RELSSPTGNP KSDASTSAQP GFASSSQSND
     DNEVTSTSSL SSLPKDRQTE DFDQYETQLG SLPQQFEEPA VISARYSGYI SDIPSTLSPY
     MSRTSLVPDP KNEGSILPGS SSYQYHQYGI KSSVPSPRSS EAIKPSQYDD DETDMEYLKV
     TDISHLMELP QNLQSLHIDS CDGLTSLPEN LTESYPNLHE LLIIACHSLE SFPGSHPPTT
     LKTLYIRDCK KLNFTESLQP TRSYSQLEYL FIGSSCSNLV NFPLSLFPKL RSLSIRDCES
     FKTFSIHAGL GDDRIALESL EIRDCPNLET FPQGGLPTPK LSSMLLSNCK KLQALPEKLF
     GLTSLLSLFI IKCPEIETIP GGGFPSNLRT LCISLCDKLT PRIEWGLRDL ENLRNLEIDG
     GNEDIESFPE EGLLPKSVFS LRISRFENLK TLNRKGFHDT KAIETMEISG CDKLQISIDE
     DLPPLSCLRI SSCSLLTETF AEVETEFFKV LNIPYVEIDG EIFS