ID   DRL23_ARATH             Reviewed;         892 AA.
AC   O82484;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=Putative disease resistance protein At4g10780;
GN   OrderedLocusNames=At4g10780; ORFNames=T12H20.8;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA   Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA   Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA   de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA   Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA   Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA   Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA   Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA   Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA   Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA   Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA   Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA   Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA   Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA   Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA   Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA   Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA   Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA   Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA   Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA   Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA   Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA   Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA   de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA   Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA   Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA   Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA   Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA   Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA   Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA   Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA   O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA   Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA   Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL   Nature 402:769-777(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
CC   -!- FUNCTION: Potential disease resistance protein. {ECO:0000250}.
CC   -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC       pathogen recognition. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC       of disease resistance gene homologs;
CC       URL="http://niblrrs.ucdavis.edu";
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DR   EMBL; AF080119; AAC35528.1; -; Genomic_DNA.
DR   EMBL; AL161518; CAB81179.1; -; Genomic_DNA.
DR   EMBL; CP002687; AEE82928.1; -; Genomic_DNA.
DR   PIR; T01899; T01899.
DR   RefSeq; NP_192816.1; NM_117146.1.
DR   AlphaFoldDB; O82484; -.
DR   SMR; O82484; -.
DR   BioGRID; 11973; 1.
DR   STRING; 3702.AT4G10780.1; -.
DR   PaxDb; O82484; -.
DR   PRIDE; O82484; -.
DR   EnsemblPlants; AT4G10780.1; AT4G10780.1; AT4G10780.
DR   GeneID; 826674; -.
DR   Gramene; AT4G10780.1; AT4G10780.1; AT4G10780.
DR   KEGG; ath:AT4G10780; -.
DR   Araport; AT4G10780; -.
DR   TAIR; locus:2132741; AT4G10780.
DR   eggNOG; KOG4658; Eukaryota.
DR   HOGENOM; CLU_000427_4_0_1; -.
DR   InParanoid; O82484; -.
DR   OrthoDB; 955025at2759; -.
DR   PhylomeDB; O82484; -.
DR   PRO; PR:O82484; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; O82484; differential.
DR   Genevisible; O82484; AT.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.8.430; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; PTHR23155; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW   Plant defense; Reference proteome; Repeat.
FT   CHAIN           1..892
FT                   /note="Putative disease resistance protein At4g10780"
FT                   /id="PRO_0000212755"
FT   DOMAIN          137..440
FT                   /note="NB-ARC"
FT   REPEAT          515..536
FT                   /note="LRR 1"
FT   REPEAT          537..559
FT                   /note="LRR 2"
FT   REPEAT          562..584
FT                   /note="LRR 3"
FT   REPEAT          586..608
FT                   /note="LRR 4"
FT   REPEAT          609..631
FT                   /note="LRR 5"
FT   REPEAT          632..654
FT                   /note="LRR 6"
FT   COILED          24..63
FT                   /evidence="ECO:0000255"
FT   BINDING         180..187
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   892 AA;  101802 MW;  FC337F081EDB357B CRC64;
     MGSCISLQIS CDQVLTRAYS CFFSLGNYIH KLKDNIVALE KAIEDLTATR DDVLRRVQME
     EGKGLERLQQ VQVWLKRVEI IRNQFYDLLS ARNIEIQRLC FYSNCSTNLS SSYTYGQRVF
     LMIKEVENLN SNGFFEIVAA PAPKLEMRPI QPTIMGRETI FQRAWNRLMD DGVGTMGLYG
     MGGVGKTTLL TQIHNTLHDT KNGVDIVIWV VVSSDLQIHK IQEDIGEKLG FIGKEWNKKQ
     ESQKAVDILN CLSKKRFVLL LDDIWKKVDL TKIGIPSQTR ENKCKVVFTT RSLDVCARMG
     VHDPMEVQCL STNDAWELFQ EKVGQISLGS HPDILELAKK VAGKCRGLPL ALNVIGETMA
     GKRAVQEWHH AVDVLTSYAA EFSGMDDHIL LILKYSYDNL NDKHVRSCFQ YCALYPEDYS
     IKKYRLIDYW ICEGFIDGNI GKERAVNQGY EILGTLVRAC LLSEEGKNKL EVKMHDVVRE
     MALWTLSDLG KNKERCIVQA GSGLRKVPKV EDWGAVRRLS LMNNGIEEIS GSPECPELTT
     LFLQENKSLV HISGEFFRHM RKLVVLDLSE NHQLDGLPEQ ISELVALRYL DLSHTNIEGL
     PACLQDLKTL IHLNLECMRR LGSIAGISKL SSLRTLGLRN SNIMLDVMSV KELHLLEHLE
     ILTIDIVSTM VLEQMIDAGT LMNCMQEVSI RCLIYDQEQD TKLRLPTMDS LRSLTMWNCE
     ISEIEIERLT WNTNPTSPCF FNLSQVIIHV CSSLKDLTWL LFAPNITYLM IEQLEQLQEL
     ISHAKATGVT EEEQQQLHKI IPFQKLQILH LSSLPELKSI YWISLSFPCL SGIYVERCPK
     LRKLPLDSKT GTVGKKFVLQ YKETEWIESV EWKDEATKLH FLPSTKLVYI LS