DRL24_ARATH
ID DRL24_ARATH Reviewed; 719 AA.
AC O23317; O64972; O82101;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Probable disease resistance protein At4g14610;
DE AltName: Full=pCol1;
GN OrderedLocusNames=At4g14610; ORFNames=dl3345c, FCAALL.272;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9461215; DOI=10.1038/35140;
RA Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C.,
RA Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., Ridley P.,
RA Hudson S.-A., Patel K., Murphy G., Piffanelli P., Wedler H., Wedler E.,
RA Wambutt R., Weitzenegger T., Pohl T., Terryn N., Gielen J., Villarroel R.,
RA De Clercq R., van Montagu M., Lecharny A., Aubourg S., Gy I., Kreis M.,
RA Lao N., Kavanagh T., Hempel S., Kotter P., Entian K.-D., Rieger M.,
RA Schaefer M., Funk B., Mueller-Auer S., Silvey M., James R., Monfort A.,
RA Pons A., Puigdomenech P., Douka A., Voukelatou E., Milioni D.,
RA Hatzopoulos P., Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A.,
RA Moores T., Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S.,
RA Ansorge W., Cooke R., Berger C., Delseny M., Voet M., Volckaert G.,
RA Mewes H.-W., Klosterman S., Schueller C., Chalwatzis N.;
RT "Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis
RT thaliana.";
RL Nature 391:485-488(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 158-328.
RC STRAIN=cv. Columbia;
RX PubMed=9670562; DOI=10.1046/j.1365-313x.1998.00138.x;
RA Speulman E., Bouchez D., Holub E.B., Beynon J.L.;
RT "Disease resistance gene homologs correlate with disease resistance loci of
RT Arabidopsis thaliana.";
RL Plant J. 14:467-474(1998).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 165-322.
RC STRAIN=cv. Columbia;
RX PubMed=9530866; DOI=10.1094/mpmi.1998.11.4.251;
RA Aarts M.G.M., te Lintel Hekkert B., Holub E.B., Beynon J.L., Stiekema W.J.,
RA Pereira A.;
RT "Identification of R-gene homologous DNA fragments genetically linked to
RT disease resistance loci in Arabidopsis thaliana.";
RL Mol. Plant Microbe Interact. 11:251-258(1998).
CC -!- FUNCTION: Probable disease resistance protein. {ECO:0000250}.
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z97336; CAB10240.1; -; Genomic_DNA.
DR EMBL; AL161539; CAB78503.1; -; Genomic_DNA.
DR EMBL; CP002687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; U97222; AAC50029.1; -; Genomic_DNA.
DR EMBL; AF039378; AAC14554.1; -; Genomic_DNA.
DR PIR; F71408; F71408.
DR AlphaFoldDB; O23317; -.
DR IntAct; O23317; 1.
DR PeptideAtlas; O23317; -.
DR PRIDE; O23317; -.
DR Araport; AT4G14610; -.
DR InParanoid; O23317; -.
DR PRO; PR:O23317; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; O23317; baseline and differential.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23155; PTHR23155; 3.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW Plant defense; Reference proteome; Repeat.
FT CHAIN 1..719
FT /note="Probable disease resistance protein At4g14610"
FT /id="PRO_0000212756"
FT DOMAIN 114..418
FT /note="NB-ARC"
FT REPEAT 400..421
FT /note="LRR 1"
FT REPEAT 422..444
FT /note="LRR 2"
FT REPEAT 447..469
FT /note="LRR 3"
FT COILED 25..73
FT /evidence="ECO:0000255"
FT BINDING 156..163
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT CONFLICT 172
FT /note="K -> R (in Ref. 4; AAC50029)"
FT /evidence="ECO:0000305"
FT CONFLICT 239
FT /note="D -> G (in Ref. 4; AAC50029)"
FT /evidence="ECO:0000305"
FT CONFLICT 241
FT /note="W -> C (in Ref. 4; AAC50029)"
FT /evidence="ECO:0000305"
FT CONFLICT 271
FT /note="V -> G (in Ref. 5; AAC14554)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 719 AA; 81918 MW; A7C353F05992CFCF CRC64;
MALTKLRFVN QFSQWLCVRK GYIHSLPENL AALQKAIEVL KTKHDDVKRR VDKEEFLGRR
HRLSQVQVEI ERLCFCGFCS KSFGKSYHYG KMVSVMLKEV ENLSSRGVFD VVTEENLVAQ
VEEMPIQSTV VGQETMLERV WNTLMKDGFK IMGLYGMGGV GKTTLLTQIN KKFSETDGGF
DIVMWVVVSK TSEIYRIQED IAKRLGLTGE EWDKKNENKR AVDIHNVLRR HKFVLLLDDI
WEKVNLELVG VPYPSRENGS IVAFTTRSRD VCGRMGVDDP MQVSCLEPED AWDLFQNKVG
ENTLKSHPDI PELAKQVAEK CRGLPLALNV IGETMACKST VQEWRHAIDE EWKKTEVKMH
DVVREMALWI SSDLGKHKDQ CIVRAGVGLH AVPEVKNWRA VRRMSLMKNE LEKILGCPTC
PQLTTLLLQK NHKLVNISGE FFRFMPNLVV LDLSWNSSLT GLPKKISEVE TTNTSEFGVH
EEFGEYAGVS KLLSLKTLRL QKSKKALDVN SAKELQLLEH IEVLTIDIFS KVEEESFKIL
TFPSMCNIRR IGIWKCGMKE IKVEMRTSSC FSSLSKVVIG QCDGLKELTW LLFAPNLTYL
DARFAEQLED IISEEKAASV TDENASIIIP FQKLECLSLS DLPKLKSIYW SPLSFPRLSE
LAVQEHCPKL KKLPLNSKSG TAGVELVVKY GENKWLEGVE WEDKATELRF LATCKSLYR
