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DRL25_ARATH
ID   DRL25_ARATH             Reviewed;        1201 AA.
AC   P0CB16; O50052;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 2.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Putative disease resistance protein At4g19050;
GN   OrderedLocusNames=At4g19050; ORFNames=F13C5.220, T18B16.1;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA   Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA   Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA   de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA   Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA   Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA   Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA   Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA   Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA   Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA   Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA   Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA   Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA   Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA   Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA   Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA   Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA   Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA   Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA   Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA   Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA   Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA   Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA   de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA   Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA   Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA   Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA   Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA   Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA   Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA   Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA   O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA   Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA   Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL   Nature 402:769-777(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE STRUCTURE.
RX   PubMed=12671079; DOI=10.1105/tpc.009308;
RA   Meyers B.C., Kozik A., Griego A., Kuang H., Michelmore R.W.;
RT   "Genome-wide analysis of NBS-LRR-encoding genes in Arabidopsis.";
RL   Plant Cell 15:809-834(2003).
CC   -!- FUNCTION: Potential disease resistance protein. {ECO:0000250}.
CC   -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC       pathogen recognition. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA16762.1; Type=Erroneous gene model prediction; Note=The predicted gene At4g19050 has been split into 2 genes: At4g19045 and At4g19050.; Evidence={ECO:0000305};
CC       Sequence=CAB78907.1; Type=Erroneous gene model prediction; Note=The predicted gene At4g19050 has been split into 2 genes: At4g19045 and At4g19050.; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC       of disease resistance gene homologs;
CC       URL="http://niblrrs.ucdavis.edu";
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DR   EMBL; AL021711; CAA16762.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL161550; CAB78907.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002687; AEE84134.1; -; Genomic_DNA.
DR   PIR; T04426; T04426.
DR   RefSeq; NP_193640.4; NM_118023.5.
DR   AlphaFoldDB; P0CB16; -.
DR   SMR; P0CB16; -.
DR   BioGRID; 12936; 1.
DR   STRING; 3702.AT4G19050.1; -.
DR   PaxDb; P0CB16; -.
DR   PRIDE; P0CB16; -.
DR   ProteomicsDB; 224322; -.
DR   EnsemblPlants; AT4G19050.1; AT4G19050.1; AT4G19050.
DR   GeneID; 827643; -.
DR   Gramene; AT4G19050.1; AT4G19050.1; AT4G19050.
DR   KEGG; ath:AT4G19050; -.
DR   Araport; AT4G19050; -.
DR   TAIR; locus:2117149; AT4G19050.
DR   eggNOG; KOG0440; Eukaryota.
DR   HOGENOM; CLU_004092_0_0_1; -.
DR   InParanoid; P0CB16; -.
DR   OMA; VERCKNM; -.
DR   OrthoDB; 352436at2759; -.
DR   PRO; PR:P0CB16; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; P0CB16; baseline and differential.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 4.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00931; NB-ARC; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Leucine-rich repeat; Nucleotide-binding; Plant defense;
KW   Reference proteome; Repeat.
FT   CHAIN           1..1201
FT                   /note="Putative disease resistance protein At4g19050"
FT                   /id="PRO_0000212757"
FT   REPEAT          469..491
FT                   /note="LRR 1"
FT   REPEAT          492..514
FT                   /note="LRR 2"
FT   REPEAT          517..539
FT                   /note="LRR 3"
FT   REPEAT          540..562
FT                   /note="LRR 4"
FT   REPEAT          680..701
FT                   /note="LRR 5"
FT   REPEAT          703..725
FT                   /note="LRR 6"
FT   REPEAT          726..748
FT                   /note="LRR 7"
FT   REPEAT          750..771
FT                   /note="LRR 8"
FT   REPEAT          773..795
FT                   /note="LRR 9"
FT   REPEAT          796..818
FT                   /note="LRR 10"
FT   REPEAT          820..841
FT                   /note="LRR 11"
FT   REPEAT          843..865
FT                   /note="LRR 12"
FT   REPEAT          866..888
FT                   /note="LRR 13"
FT   REPEAT          890..911
FT                   /note="LRR 14"
FT   REGION          1162..1201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1162..1180
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1181..1201
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         33..40
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1201 AA;  136827 MW;  0108CC8A0F1121F9 CRC64;
     MEKQDQTSRE EILKKIMDSL GQDGVPSKTV LVGEAGIGKT WLAKEVSQRV TQEKYNVLWL
     HLNKKIEDEK SLYEILAAQL SIIYEFEEGE EPDELDYPLE SLKEKIKEEM IKHKKDNLLL
     ILDDEGSMTT EEDVMQELNL QDFLKEYSAV KILVTRRDER EEKESTTIKV GPLTEKESLD
     LLHDAEDLLT SFTSEDWPVL LKRLCDNKEI KEPTLMSCIL SKSKGLPAAI VVLIKSLNSI
     KSMSAKQRKI FKELILSSKS LDEAAASKNA IDRSRYNPVL QLSYELLKPD ETVKRPVIAC
     FWHILDFYKY SGCAYYRDLI VHWMLEGYFD PVKSVDKAYQ EGHSILMDFM NRGILKIQED
     NMVVPEFSMS NLLDLQDCGF FGRSSLGFDR VYGGDKRKGL GKIILIDDMI QTIQSKKKNI
     TTIIASGNRL RREVHGKFFE KPEMQDLEVV VLFEPTFHEL VLSLSKLKKL RVLVIRDCDL
     IDNIDKLSGL QGLHVLEVSG ASSLVNIPDD FFKNMTQLQS LNLSGLAIKS SPSTIEKLSM
     LRCFILRHCS ELQDLPNFIV ETRKLEVIDI HGARKLESYF DRVKDWKDYK GKNKNFAQLQ
     LLEHLDFSET KIIRLPIFHL KDSTNDFSTM PILTRLLLRN CTRLKRLPQL RPLTNLQILD
     ACGATDLVEM LEVCLEEKKE LRILDMSKTS LPELADTIAD VVNLNKLLLR NCSLIEELPS
     IEKLTHLEVF DVSGCIKLKN INGSFGEMSY LHEVNLSETN LSELPDKISE LSNLKELIIR
     KCSKLKTLPN LEKLTNLEIF DVSGCTELET IEGSFENLSC LHKVNLSETN LGELPNKISE
     LSNLKELILR NCSKLKALPN LEKLTHLVIF DVSGCTNLDK IEESFESMSY LCEVNLSGTN
     LKTFPELPKQ SILCSSKRIV LADSSCIERD QWSQIKECLT SKSEGSSFSN VGEKTREKLL
     YHGNRYRVID PEVPLNIDIV DIKRSTDLKT EYIAKAEYVS IAENGSKSVS SLFDELQMAS
     VKGCWVERCK NMDVLFESDE QLEKEKSSSP SLQTLWISNL PLLTSLYSSK GGFIFKNLKK
     LSVDCCPSIK WLFPEIPDNL EILRVKFCDK LERLFEVKAG ELSKLRKLHL LDLPVLSVLG
     ANFPNLEKCT IEKCPKLKAR EDEPRIGARI TDEISEDQPH KNTIGPETQT PTQPTKATDT
     V
 
 
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