DRL28_ARATH
ID DRL28_ARATH Reviewed; 919 AA.
AC O81825; Q1PE46;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Probable disease resistance protein At4g27220;
GN OrderedLocusNames=At4g27220; ORFNames=M4I22.30;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
CC -!- FUNCTION: Probable disease resistance protein. {ECO:0000250}.
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL030978; CAA19716.1; -; Genomic_DNA.
DR EMBL; AL161566; CAB79577.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE85312.1; -; Genomic_DNA.
DR EMBL; DQ446872; ABE66093.1; -; mRNA.
DR PIR; T05746; T05746.
DR RefSeq; NP_194452.1; NM_118856.1.
DR AlphaFoldDB; O81825; -.
DR SMR; O81825; -.
DR STRING; 3702.AT4G27220.1; -.
DR PaxDb; O81825; -.
DR PRIDE; O81825; -.
DR EnsemblPlants; AT4G27220.1; AT4G27220.1; AT4G27220.
DR GeneID; 828830; -.
DR Gramene; AT4G27220.1; AT4G27220.1; AT4G27220.
DR KEGG; ath:AT4G27220; -.
DR Araport; AT4G27220; -.
DR TAIR; locus:2131689; AT4G27220.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000427_2_0_1; -.
DR InParanoid; O81825; -.
DR OMA; AIWIMSP; -.
DR PhylomeDB; O81825; -.
DR PRO; PR:O81825; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; O81825; baseline and differential.
DR Genevisible; O81825; AT.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW Plant defense; Reference proteome; Repeat.
FT CHAIN 1..919
FT /note="Probable disease resistance protein At4g27220"
FT /id="PRO_0000212760"
FT DOMAIN 121..399
FT /note="NB-ARC"
FT REPEAT 447..468
FT /note="LRR 1"
FT REPEAT 469..492
FT /note="LRR 2"
FT REPEAT 494..516
FT /note="LRR 3"
FT REPEAT 519..540
FT /note="LRR 4"
FT REPEAT 542..564
FT /note="LRR 5"
FT REPEAT 565..587
FT /note="LRR 6"
FT REPEAT 588..610
FT /note="LRR 7"
FT REPEAT 611..635
FT /note="LRR 8"
FT COILED 1..30
FT /evidence="ECO:0000255"
FT COILED 74..95
FT /evidence="ECO:0000255"
FT BINDING 141..148
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 919 AA; 103914 MW; 3C844D04ADC00CD3 CRC64;
MFRSNARALN RALERLKNVQ TKVNEALKRS GIQEKSLERK LRIWLRKVEE NVPLGELILE
KRSSCAIWLS DKDVEILEKV KRLEEQGQDL IKKISVNKSS REIVERVLGP SFHPQKTALE
MLDKLKDCLK KKNVQKIGVW GMGGVGKTTL VRTLNNDLLK YAATQQFALV IWVTVSKDFD
LKRVQMDIAK RLGKRFTREQ MNQLGLTICE RLIDLKNFLL ILDDVWHPID LDQLGIPLAL
ERSKDSKVVL TSRRLEVCQQ MMTNENIKVA CLQEKEAWEL FCHNVGEVAN SDNVKPIAKD
VSHECCGLPL AIITIGRTLR GKPQVEVWKH TLNLLKRSAP SIDTEEKIFG TLKLSYDFLQ
DNMKSCFLFC ALFPEDYSIK VSELIMYWVA EGLLDGQHHY EDMMNEGVTL VERLKDSCLL
EDGDSCDTVK MHDVVRDFAI WFMSSQGEGF HSLVMAGRGL IEFPQDKFVS SVQRVSLMAN
KLERLPNNVI EGVETLVLLL QGNSHVKEVP NGFLQAFPNL RILDLSGVRI RTLPDSFSNL
HSLRSLVLRN CKKLRNLPSL ESLVKLQFLD LHESAIRELP RGLEALSSLR YICVSNTYQL
QSIPAGTILQ LSSLEVLDMA GSAYSWGIKG EEREGQATLD EVTCLPHLQF LAIKLLDVLS
FSYEFDSLTK RLTKFQFLFS PIRSVSPPGT GEGCLAISDV NVSNASIGWL LQHVTSLDLN
YCEGLNGMFE NLVTKSKSSF VAMKALSIHY FPSLSLASGC ESQLDLFPNL EELSLDNVNL
ESIGELNGFL GMRLQKLKLL QVSGCRQLKR LFSDQILAGT LPNLQEIKVV SCLRLEELFN
FSSVPVDFCA ESLLPKLTVI KLKYLPQLRS LCNDRVVLES LEHLEVESCE SLKNLPFVPG
NTGMINEQMA WEYMSRTLG