DRL29_ARATH
ID DRL29_ARATH Reviewed; 816 AA.
AC Q9SZA7; B9DG00; Q56WJ3;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2011, sequence version 3.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Probable disease resistance protein At4g33300;
GN OrderedLocusNames=At4g33300; ORFNames=F17M5.60;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 451-816.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable disease resistance protein. {ECO:0000250}.
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB38788.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB80047.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
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DR EMBL; AL035678; CAB38788.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161583; CAB80047.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE86203.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE86204.1; -; Genomic_DNA.
DR EMBL; AK316970; BAH19667.1; -; mRNA.
DR EMBL; AK222047; BAD94804.1; -; mRNA.
DR PIR; T05981; T05981.
DR RefSeq; NP_001031781.1; NM_001036704.2.
DR RefSeq; NP_001320123.1; NM_001342211.1.
DR AlphaFoldDB; Q9SZA7; -.
DR SMR; Q9SZA7; -.
DR STRING; 3702.AT4G33300.2; -.
DR iPTMnet; Q9SZA7; -.
DR PaxDb; Q9SZA7; -.
DR PRIDE; Q9SZA7; -.
DR ProteomicsDB; 224326; -.
DR EnsemblPlants; AT4G33300.1; AT4G33300.1; AT4G33300.
DR EnsemblPlants; AT4G33300.2; AT4G33300.2; AT4G33300.
DR GeneID; 829466; -.
DR Gramene; AT4G33300.1; AT4G33300.1; AT4G33300.
DR Gramene; AT4G33300.2; AT4G33300.2; AT4G33300.
DR KEGG; ath:AT4G33300; -.
DR Araport; AT4G33300; -.
DR TAIR; locus:2119196; AT4G33300.
DR eggNOG; ENOG502QSSA; Eukaryota.
DR HOGENOM; CLU_012216_1_0_1; -.
DR InParanoid; Q9SZA7; -.
DR OMA; MAASIEC; -.
DR OrthoDB; 175097at2759; -.
DR PHI-base; PHI:2389; -.
DR PRO; PR:Q9SZA7; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9SZA7; baseline and differential.
DR Genevisible; Q9SZA7; AT.
DR GO; GO:0048046; C:apoplast; HDA:TAIR.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042742; P:defense response to bacterium; IGI:TAIR.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008808; Powdery_mildew-R_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR11017; PTHR11017; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF05659; RPW8; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51153; RPW8; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW Plant defense; Reference proteome; Repeat.
FT CHAIN 1..816
FT /note="Probable disease resistance protein At4g33300"
FT /id="PRO_0000212761"
FT DOMAIN 1..149
FT /note="RPW8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00495"
FT DOMAIN 191..443
FT /note="NB-ARC"
FT REPEAT 681..704
FT /note="LRR 1"
FT REPEAT 705..727
FT /note="LRR 2"
FT REPEAT 729..751
FT /note="LRR 3"
FT REPEAT 753..774
FT /note="LRR 4"
FT COILED 95..111
FT /evidence="ECO:0000255"
FT COILED 399..415
FT /evidence="ECO:0000255"
FT BINDING 207..214
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 816 AA; 91819 MW; 339F285A7EE3E496 CRC64;
MAITDFFAGE IATELLKQLF TISTTAWRYK NTAKQLLTLI DSIRPTIKEI QYSGVELPAH
RQAQIGMLFD TLEKGKKLTD KVLSSKRWNL YRQLTLARKM EKLEKTISNF LKNEVFTHIL
ADVHHLRADT SVRLDRVDMS LDRVIQQVGS MKIGGGGLIS EAMKRAEAME IETNDDSEKF
GVGLELGKVK VKKMMFESQG GVFGISGMGG VGKTTLAKEL QRDHEVQCHF ENRILFLTVS
QSPLLEELRE LIWGFLSGCE AGNPVPDCNF PFDGARKLVI LDDVWTTQAL DRLTSFKFPG
CTTLVVSRSK LTEPKFTYDV EVLSEDEAIS LFCLCAFGQK SIPLGFCKDL VKQVANECKG
LPLALKVTGA SLNGKPEMYW KGVLQRLSKG EPADDSHESR LLRQMEASLD NLDQTTKDCF
LDLGAFPEDR KIPLDVLINI WIELHDIDEG NAFAILVDLS HKNLLTLGKD PRLGSLYASH
YDIFVTQHDV LRDLALHLSN AGKVNRRKRL LMPKRELDLP GDWERNNDEH YIAQIVSIHT
GEMNEMQWFD MEFPKAEILI LNFSSDKYVL PPFISKMSRL KVLVIINNGM SPAVLHDFSI
FAHLSKLRSL WLERVHVPQL SNSTTPLKNL HKMSLILCKI NKSFDQTGLD VADIFPKLGD
LTIDHCDDLV ALPSSICGLT SLSCLSITNC PRLGELPKNL SKLQALEILR LYACPELKTL
PGEICELPGL KYLDISQCVS LSCLPEEIGK LKKLEKIDMR ECCFSDRPSS AVSLKSLRHV
ICDTDVAFMW EEVEKAVPGL KIEAAEKCFS LDWLDE
