ID   DRL2_ARATH              Reviewed;         884 AA.
AC   P60839; Q9LNB5;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2004, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Probable disease resistance protein At1g12290;
GN   OrderedLocusNames=At1g12290; ORFNames=F5O11.3;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
CC   -!- FUNCTION: Probable disease resistance protein. {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences.;
CC       Name=1;
CC         IsoId=P60839-1; Sequence=Displayed;
CC   -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC       pathogen recognition. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF79659.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC       of disease resistance gene homologs;
CC       URL="http://niblrrs.ucdavis.edu";
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DR   EMBL; AC025416; AAF79659.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE28862.1; -; Genomic_DNA.
DR   RefSeq; NP_172693.1; NM_101101.5. [P60839-1]
DR   AlphaFoldDB; P60839; -.
DR   SMR; P60839; -.
DR   STRING; 3702.AT1G12290.1; -.
DR   PaxDb; P60839; -.
DR   PRIDE; P60839; -.
DR   ProteomicsDB; 224327; -. [P60839-1]
DR   EnsemblPlants; AT1G12290.1; AT1G12290.1; AT1G12290. [P60839-1]
DR   GeneID; 837783; -.
DR   Gramene; AT1G12290.1; AT1G12290.1; AT1G12290. [P60839-1]
DR   KEGG; ath:AT1G12290; -.
DR   Araport; AT1G12290; -.
DR   TAIR; locus:2034765; AT1G12290.
DR   eggNOG; KOG4658; Eukaryota.
DR   OMA; IMIERNT; -.
DR   OrthoDB; 236715at2759; -.
DR   PhylomeDB; P60839; -.
DR   PRO; PR:P60839; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; P60839; baseline and differential.
DR   Genevisible; P60839; AT.
DR   GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0010942; P:positive regulation of cell death; IMP:TAIR.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.8.430; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; PTHR23155; 2.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; ATP-binding; Coiled coil; Leucine-rich repeat;
KW   Nucleotide-binding; Plant defense; Reference proteome; Repeat.
FT   CHAIN           1..884
FT                   /note="Probable disease resistance protein At1g12290"
FT                   /id="PRO_0000212734"
FT   DOMAIN          139..443
FT                   /note="NB-ARC"
FT   REPEAT          519..540
FT                   /note="LRR 1"
FT   REPEAT          541..563
FT                   /note="LRR 2"
FT   REPEAT          566..588
FT                   /note="LRR 3"
FT   REPEAT          590..612
FT                   /note="LRR 4"
FT   REPEAT          613..635
FT                   /note="LRR 5"
FT   REPEAT          644..664
FT                   /note="LRR 6"
FT   COILED          26..66
FT                   /evidence="ECO:0000255"
FT   BINDING         182..189
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   884 AA;  100503 MW;  415C37FE753C2CA9 CRC64;
     MGGCVSVQVS CDQLLNHLGR CFCRKLYYIQ NIKENLTSLE EAMEDLKALR DDLLRKVQTA
     EEGGLQRLHQ IKVWLKRVKT IESQFNDLDS SRTVELQRLC CCGVGSRNLR LSYDYGRRVF
     LMLNIVEDLK SKGIFEEVAH PATRAVGEER PLQPTIVGQE TILEKAWDHL MDDGTKIMGL
     YGMGGVGKTT LLTQINNRFC DTDDGVEIVI WVVVSGDLQI HKIQKEIGEK IGFIGVEWNQ
     KSENQKAVDI LNFLSKKRFV LLLDDIWKRV ELTEIGIPNP TSENGCKIAF TTRCQSVCAS
     MGVHDPMEVR CLGADDAWDL FKKKVGDITL SSHPDIPEIA RKVAQACCGL PLALNVIGET
     MACKKTTQEW DRAVDVSTTY AANFGAVKER ILPILKYSYD NLESESVKTC FLYCSLFPED
     DLIEKERLID YWICEGFIDG DENKKGAVGE GYEILGTLVC ASLLVEGGKF NNKSYVKMHD
     VVREMALWIA SDLRKHKDNC IVRAGFRLNE IPKVKDWKVV SRMSLVNNRI KEIHGSPECP
     KLTTLFLQDN RHLVNISGEF FRSMPRLVVL DLSWNVNLSG LPDQISELVS LRYLDLSYSS
     IGRLPVGLLK LKKLMHLNLE SMLCLESVSG IDHLSNLKTV RLLNLRMWLT ISLLEELERL
     ENLEVLTIEI ISSSALEQLL CSHRLVRCLQ KVSVKYLDEE SVRILTLPSI GDLREVFIGG
     CGMRDIIIER NTSLTSPCFP NLSKVLITGC NGLKDLTWLL FAPNLTHLNV WNSRQIEEII
     SQEKASTADI VPFRKLEYLH LWDLPELKSI YWNPLPFPCL NQINVQNKCR KLTKLPLDSQ
     SCIVAGEELV IQYGDEEWKE RVEWEDKATR LRFLPSCKLV LCNR