DRL30_ARATH
ID DRL30_ARATH Reviewed; 811 AA.
AC Q9LZ25;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Probable disease resistance protein At5g04720;
GN OrderedLocusNames=At5g04720; ORFNames=MUK11.4, T1E3.80;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9501997; DOI=10.1093/dnares/4.6.401;
RA Nakamura Y., Sato S., Kaneko T., Kotani H., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. III. Sequence
RT features of the regions of 1,191,918 bp covered by seventeen physically
RT assigned P1 clones.";
RL DNA Res. 4:401-414(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- FUNCTION: Probable disease resistance protein. {ECO:0000250}.
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB008271; BAB08976.1; -; Genomic_DNA.
DR EMBL; AL162972; CAB86014.1; -; Genomic_DNA.
DR EMBL; CP002688; AED90775.1; -; Genomic_DNA.
DR EMBL; AY050794; AAK92729.1; -; mRNA.
DR EMBL; AY113952; AAM45000.1; -; mRNA.
DR PIR; T48468; T48468.
DR RefSeq; NP_196092.1; NM_120554.2.
DR AlphaFoldDB; Q9LZ25; -.
DR SMR; Q9LZ25; -.
DR STRING; 3702.AT5G04720.1; -.
DR iPTMnet; Q9LZ25; -.
DR PaxDb; Q9LZ25; -.
DR PRIDE; Q9LZ25; -.
DR ProteomicsDB; 224328; -.
DR EnsemblPlants; AT5G04720.1; AT5G04720.1; AT5G04720.
DR GeneID; 830350; -.
DR Gramene; AT5G04720.1; AT5G04720.1; AT5G04720.
DR KEGG; ath:AT5G04720; -.
DR Araport; AT5G04720; -.
DR TAIR; locus:2175433; AT5G04720.
DR eggNOG; ENOG502QU6E; Eukaryota.
DR HOGENOM; CLU_012216_1_0_1; -.
DR InParanoid; Q9LZ25; -.
DR OMA; ILINMWV; -.
DR OrthoDB; 175097at2759; -.
DR PhylomeDB; Q9LZ25; -.
DR PHI-base; PHI:2390; -.
DR PRO; PR:Q9LZ25; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LZ25; baseline and differential.
DR Genevisible; Q9LZ25; AT.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0042742; P:defense response to bacterium; IGI:TAIR.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 1.20.930.20; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR036537; Adaptor_Cbl_N_dom_sf.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008808; Powdery_mildew-R_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR11017; PTHR11017; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF05659; RPW8; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51153; RPW8; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Leucine-rich repeat; Nucleotide-binding; Plant defense;
KW Reference proteome; Repeat.
FT CHAIN 1..811
FT /note="Probable disease resistance protein At5g04720"
FT /id="PRO_0000212762"
FT DOMAIN 1..147
FT /note="RPW8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00495"
FT DOMAIN 180..242
FT /note="NB-ARC 1"
FT DOMAIN 312..437
FT /note="NB-ARC 2"
FT REPEAT 650..674
FT /note="LRR 1"
FT REPEAT 676..699
FT /note="LRR 3"
FT REPEAT 700..722
FT /note="LRR 3"
FT REPEAT 724..746
FT /note="LRR 4"
FT REPEAT 748..769
FT /note="LRR 5"
FT BINDING 207..214
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 811 AA; 91537 MW; 51FA7553F496BE87 CRC64;
MADIIGGEVV TELVRQLYAV SQKTLRCRGI AKNLATMIDG LQPTIKEIQY SGVELTPHRQ
AQLRMFSETL DKCRKLTEKV LKSSRWNMVR QLLHVRKMEN LQSKVSSFLN GQLLVHVLAD
VHHVRADSEF RFDRIDRKVD SLNEKLGSMK LRGSESLREA LKTAEATVEM VTTDGADLGV
GLDLGKRKVK EMLFKSIDGE RLIGISGMSG SGKTTLAKEL ARDEEVRGHF GNKVLFLTVS
QSPNLEELRA HIWGFLTSYE AGVGATLPES RKLVILDDVW TRESLDQLMF ENIPGTTTLV
VSRSKLADSR VTYDVELLNE HEATALFCLS VFNQKLVPSG FSQSLVKQVV GECKGLPLSL
KVIGASLKER PEKYWEGAVE RLSRGEPADE THESRVFAQI EATLENLDPK TRDCFLVLGA
FPEDKKIPLD VLINVLVELH DLEDATAFAV IVDLANRNLL TLVKDPRFGH MYTSYYDIFV
TQHDVLRDVA LRLSNHGKVN NRERLLMPKR ESMLPREWER NNDEPYKARV VSIHTGEMTQ
MDWFDMELPK AEVLILHFSS DKYVLPPFIA KMGKLTALVI INNGMSPARL HDFSIFTNLA
KLKSLWLQRV HVPELSSSTV PLQNLHKLSL IFCKINTSLD QTELDIAQIF PKLSDLTIDH
CDDLLELPST ICGITSLNSI SITNCPRIKE LPKNLSKLKA LQLLRLYACH ELNSLPVEIC
ELPRLKYVDI SQCVSLSSLP EKIGKVKTLE KIDTRECSLS SIPNSVVLLT SLRHVICDRE
ALWMWEKVQK AVAGLRVEAA EKSFSRDWLD D
