ID   DRL31_ARATH             Reviewed;         874 AA.
AC   Q9FLB4;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Putative disease resistance protein At5g05400;
GN   OrderedLocusNames=At5g05400; ORFNames=K18I23.21;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA   Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT   features of the regions of 1,381,565 bp covered by twenty one physically
RT   assigned P1 and TAC clones.";
RL   DNA Res. 5:131-145(1998).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
CC   -!- FUNCTION: Potential disease resistance protein. {ECO:0000250}.
CC   -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC       pathogen recognition. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC       of disease resistance gene homologs;
CC       URL="http://niblrrs.ucdavis.edu";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB010692; BAB09983.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED90869.1; -; Genomic_DNA.
DR   RefSeq; NP_196159.1; NM_120622.2.
DR   AlphaFoldDB; Q9FLB4; -.
DR   SMR; Q9FLB4; -.
DR   STRING; 3702.AT5G05400.1; -.
DR   PaxDb; Q9FLB4; -.
DR   PRIDE; Q9FLB4; -.
DR   ProteomicsDB; 224329; -.
DR   EnsemblPlants; AT5G05400.1; AT5G05400.1; AT5G05400.
DR   GeneID; 830422; -.
DR   Gramene; AT5G05400.1; AT5G05400.1; AT5G05400.
DR   KEGG; ath:AT5G05400; -.
DR   Araport; AT5G05400; -.
DR   TAIR; locus:2153474; AT5G05400.
DR   eggNOG; KOG4658; Eukaryota.
DR   HOGENOM; CLU_000427_4_0_1; -.
DR   InParanoid; Q9FLB4; -.
DR   OMA; ILWITRE; -.
DR   OrthoDB; 282372at2759; -.
DR   PhylomeDB; Q9FLB4; -.
DR   PRO; PR:Q9FLB4; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FLB4; baseline and differential.
DR   Genevisible; Q9FLB4; AT.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.8.430; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; PTHR23155; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   SMART; SM00369; LRR_TYP; 2.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW   Plant defense; Reference proteome; Repeat.
FT   CHAIN           1..874
FT                   /note="Putative disease resistance protein At5g05400"
FT                   /id="PRO_0000212763"
FT   DOMAIN          139..434
FT                   /note="NB-ARC"
FT   REPEAT          483..505
FT                   /note="LRR 1"
FT   REPEAT          506..527
FT                   /note="LRR 2"
FT   REPEAT          528..548
FT                   /note="LRR 3"
FT   REPEAT          552..574
FT                   /note="LRR 4"
FT   REPEAT          575..597
FT                   /note="LRR 5"
FT   REPEAT          598..620
FT                   /note="LRR 6"
FT   REPEAT          621..642
FT                   /note="LRR 7"
FT   COILED          22..74
FT                   /evidence="ECO:0000255"
FT   BINDING         182..189
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   874 AA;  99757 MW;  1DD55D0C163B1711 CRC64;
     MGACFSVAIS CDQAVNNLTS CLSRNQNRFR NLVDHVAALK KTVRQLEARR DDLLKRIKVQ
     EDRGLNLLDE VQQWLSEVES RVCEAHDILS QSDEEIDNLC CGQYCSKRCK YSYDYSKSVI
     NKLQDVENLL SKGVFDEVAQ KGPIPKVEER LFHQEIVGQE AIVESTWNSM MEVGVGLLGI
     YGMGGVGKTT LLSQINNKFR TVSNDFDIAI WVVVSKNPTV KRIQEDIGKR LDLYNEGWEQ
     KTENEIASTI KRSLENKKYM LLLDDMWTKV DLANIGIPVP KRNGSKIAFT SRSNEVCGKM
     GVDKEIEVTC LMWDDAWDLF TRNMKETLES HPKIPEVAKS IARKCNGLPL ALNVIGETMA
     RKKSIEEWHD AVGVFSGIEA DILSILKFSY DDLKCEKTKS CFLFSALFPE DYEIGKDDLI
     EYWVGQGIIL GSKGINYKGY TIIGTLTRAY LLKESETKEK VKMHDVVREM ALWISSGCGD
     QKQKNVLVVE ANAQLRDIPK IEDQKAVRRM SLIYNQIEEA CESLHCPKLE TLLLRDNRLR
     KISREFLSHV PILMVLDLSL NPNLIELPSF SPLYSLRFLN LSCTGITSLP DGLYALRNLL
     YLNLEHTYML KRIYEIHDLP NLEVLKLYAS GIDITDKLVR QIQAMKHLYL LTITLRNSSG
     LEIFLGDTRF SSYTEGLTLD EQSYYQSLKV PLATISSSRF LEIQDSHIPK IEIEGSSSNE
     SEIVGPRVRR DISFINLRKV RLDNCTGLKD LTWLVFAPHL ATLYVVCLPD IEHIISRSEE
     SRLQKTCELA GVIPFRELEF LTLRNLGQLK SIYRDPLLFG KLKEINIKSC PKLTKLPLDS
     RSAWKQNVVI NAEEEWLQGL QWEDVATKER FFPS