DRL33_ARATH
ID DRL33_ARATH Reviewed; 862 AA.
AC Q9FG90;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Probable disease resistance protein At5g43740;
GN OrderedLocusNames=At5g43740; ORFNames=MQD19.7;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- FUNCTION: Probable disease resistance protein. {ECO:0000250}.
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
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DR EMBL; AB026651; BAB11301.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95002.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95003.1; -; Genomic_DNA.
DR EMBL; AY050380; AAK91398.1; -; mRNA.
DR EMBL; BT000491; AAN18060.1; -; mRNA.
DR RefSeq; NP_199187.1; NM_123740.5.
DR RefSeq; NP_851126.1; NM_180795.3.
DR AlphaFoldDB; Q9FG90; -.
DR SMR; Q9FG90; -.
DR STRING; 3702.AT5G43740.2; -.
DR PaxDb; Q9FG90; -.
DR PRIDE; Q9FG90; -.
DR ProteomicsDB; 224331; -.
DR EnsemblPlants; AT5G43740.1; AT5G43740.1; AT5G43740.
DR EnsemblPlants; AT5G43740.2; AT5G43740.2; AT5G43740.
DR GeneID; 834394; -.
DR Gramene; AT5G43740.1; AT5G43740.1; AT5G43740.
DR Gramene; AT5G43740.2; AT5G43740.2; AT5G43740.
DR KEGG; ath:AT5G43740; -.
DR Araport; AT5G43740; -.
DR TAIR; locus:2170902; AT5G43740.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000427_4_0_1; -.
DR InParanoid; Q9FG90; -.
DR OMA; QVISDEC; -.
DR OrthoDB; 257031at2759; -.
DR PhylomeDB; Q9FG90; -.
DR PRO; PR:Q9FG90; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FG90; baseline and differential.
DR Genevisible; Q9FG90; AT.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW Plant defense; Reference proteome; Repeat.
FT CHAIN 1..862
FT /note="Probable disease resistance protein At5g43740"
FT /id="PRO_0000212765"
FT DOMAIN 135..438
FT /note="NB-ARC"
FT REPEAT 511..532
FT /note="LRR 1"
FT REPEAT 533..555
FT /note="LRR 2"
FT REPEAT 558..580
FT /note="LRR 3"
FT REPEAT 582..604
FT /note="LRR 4"
FT COILED 24..61
FT /evidence="ECO:0000255"
FT BINDING 178..185
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 862 AA; 98473 MW; 8955414B775DBA30 CRC64;
MLGWLVIPWN QIFTAACGCF LSDRNYIHMM ESNLDALQKT MEELKNGRDD LLGRVSIEED
KGLQRLAQVN GWLSRVQIVE SEFKDLLEAM SIETGRLCLL GYCSEDCISS YNYGEKVSKM
LEEVKELLSK KDFRMVAQEI IHKVEKKLIQ TTVGLDKLVE MAWSSLMNDE IGTLGLYGMG
GVGKTTLLES LNNKFVELES EFDVVIWVVV SKDFQFEGIQ DQILGRLRSD KEWERETESK
KASLIYNNLE RKKFVLLLDD LWSEVDMTKI GVPPPTRENG SKIVFTTRST EVCKHMKADK
QIKVACLSPD EAWELFRLTV GDIILRSHQD IPALARIVAA KCHGLPLALN VIGKAMSCKE
TIQEWSHAIN VLNSAGHEFP GMEERILPIL KFSYDSLKNG EIKLCFLYCS LFPEDSEIPK
EKWIEYWICE GFINPNRYED GGTNHGYDII GLLVRAHLLI ECELTDNVKM HDVIREMALW
INSDFGKQQE TICVKSGAHV RMIPNDINWE IVRTMSFTCT QIKKISCRSK CPNLSTLLIL
DNRLLVKISN RFFRFMPKLV VLDLSANLDL IKLPEEISNL GSLQYLNISL TGIKSLPVGL
KKLRKLIYLN LEFTGVHGSL VGIAATLPNL QVLKFFYSCV YVDDILMKEL QDLEHLKILT
ANVKDVTILE RIQGDDRLAS SIRSLCLEDM STPRVILSTI ALGGLQQLAI LMCNISEIRI
DWESKERREL SPTEILPSTG SPGFKQLSTV YINQLEGQRD LSWLLYAQNL KKLEVCWSPQ
IEEIINKEKG MNITKLHRDI VVPFGNLEDL ALRQMADLTE ICWNYRTLPN LRKSYINDCP
KLPEDIFVPL LPEKSPSRFF FF
