ID   DRL34_ARATH             Reviewed;         346 AA.
AC   Q9FHJ2;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Probable disease resistance protein At5g45440;
GN   OrderedLocusNames=At5g45440; ORFNames=MFC19.11;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10470850; DOI=10.1093/dnares/6.3.183;
RA   Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Kotani H.,
RA   Miyajima N., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. IX. Sequence
RT   features of the regions of 1,011,550 bp covered by seventeen P1 and TAC
RT   clones.";
RL   DNA Res. 6:183-195(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
CC   -!- FUNCTION: Possible disease resistance protein. {ECO:0000250}.
CC   -!- CAUTION: Although strongly related to the NB-LRR family, it is shorter
CC       and lacks the LRR repeats that are present in other proteins of the
CC       family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC       of disease resistance gene homologs;
CC       URL="http://niblrrs.ucdavis.edu";
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DR   EMBL; AB018113; BAB09172.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED95252.1; -; Genomic_DNA.
DR   EMBL; BT006374; AAP21182.1; -; mRNA.
DR   RefSeq; NP_199357.1; NM_123912.3.
DR   AlphaFoldDB; Q9FHJ2; -.
DR   SMR; Q9FHJ2; -.
DR   BioGRID; 19829; 1.
DR   IntAct; Q9FHJ2; 1.
DR   STRING; 3702.AT5G45440.1; -.
DR   PaxDb; Q9FHJ2; -.
DR   PRIDE; Q9FHJ2; -.
DR   ProteomicsDB; 224332; -.
DR   DNASU; 834580; -.
DR   EnsemblPlants; AT5G45440.1; AT5G45440.1; AT5G45440.
DR   GeneID; 834580; -.
DR   Gramene; AT5G45440.1; AT5G45440.1; AT5G45440.
DR   KEGG; ath:AT5G45440; -.
DR   Araport; AT5G45440; -.
DR   TAIR; locus:2163498; AT5G45440.
DR   eggNOG; ENOG502RPBY; Eukaryota.
DR   HOGENOM; CLU_740453_0_0_1; -.
DR   InParanoid; Q9FHJ2; -.
DR   OMA; YDAARIY; -.
DR   OrthoDB; 1057292at2759; -.
DR   PhylomeDB; Q9FHJ2; -.
DR   PRO; PR:Q9FHJ2; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FHJ2; baseline and differential.
DR   Genevisible; Q9FHJ2; AT.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR23155; PTHR23155; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Nucleotide-binding; Plant defense; Reference proteome.
FT   CHAIN           1..346
FT                   /note="Probable disease resistance protein At5g45440"
FT                   /id="PRO_0000212766"
FT   DOMAIN          38..116
FT                   /note="NB-ARC"
FT   REGION          315..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        332..346
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         85..92
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   346 AA;  39446 MW;  FF03F84E328D43CD CRC64;
     MTQEDSSRGL TSVGRVDFTN RFADRYNEWL GTTGDETKQV EDRVETDSGL PGHDIYGFEN
     EIKSLQHFLL DQKSYKLFKS LVVVGEYGVG KTALCQQIFN DYDVRNAYAP RIWVSMHSNE
     SKEGLDGKIC VLKTILKGLG VEESMFESIH REVVEEVSNR QEAGEIDGET AKEKEISALL
     YALHLNLRWK KYLIVFDDVQ EIDNWDEKLD AKLNEGEKWG KYLSDGFPKG SGGRVIYTTR
     DENLAKNLVV QKHEIHRLWP LSDSNSVWKI YEAMIQKREK ESPRNDKKCI DELMNKSRGL
     PLAARLLAEL DPMLFDDGKA NQNGSKDGKT DSVDNPNSEE SKTKPL