ID   DRL35_ARATH             Reviewed;         354 AA.
AC   Q9FHI7;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Probable disease resistance protein At5g45490;
GN   OrderedLocusNames=At5g45490; ORFNames=MFC19.16;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10470850; DOI=10.1093/dnares/6.3.183;
RA   Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Kotani H.,
RA   Miyajima N., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. IX. Sequence
RT   features of the regions of 1,011,550 bp covered by seventeen P1 and TAC
RT   clones.";
RL   DNA Res. 6:183-195(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
CC   -!- FUNCTION: Possible disease resistance protein. {ECO:0000250}.
CC   -!- CAUTION: Although strongly related to the NB-LRR family, it is shorter
CC       and lacks the LRR repeats that are present in other proteins of the
CC       family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC       of disease resistance gene homologs;
CC       URL="http://niblrrs.ucdavis.edu";
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DR   EMBL; AB018113; BAB09177.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED95258.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED95259.1; -; Genomic_DNA.
DR   EMBL; AY065019; AAL57661.1; -; mRNA.
DR   EMBL; AY090327; AAL90988.1; -; mRNA.
DR   RefSeq; NP_001078718.1; NM_001085249.1.
DR   RefSeq; NP_199362.1; NM_123917.4.
DR   AlphaFoldDB; Q9FHI7; -.
DR   BioGRID; 19834; 2.
DR   IntAct; Q9FHI7; 2.
DR   STRING; 3702.AT5G45490.1; -.
DR   iPTMnet; Q9FHI7; -.
DR   PaxDb; Q9FHI7; -.
DR   PRIDE; Q9FHI7; -.
DR   ProteomicsDB; 224333; -.
DR   EnsemblPlants; AT5G45490.1; AT5G45490.1; AT5G45490.
DR   EnsemblPlants; AT5G45490.2; AT5G45490.2; AT5G45490.
DR   GeneID; 834585; -.
DR   Gramene; AT5G45490.1; AT5G45490.1; AT5G45490.
DR   Gramene; AT5G45490.2; AT5G45490.2; AT5G45490.
DR   KEGG; ath:AT5G45490; -.
DR   Araport; AT5G45490; -.
DR   TAIR; locus:2163568; AT5G45490.
DR   eggNOG; ENOG502RPBY; Eukaryota.
DR   HOGENOM; CLU_740453_0_0_1; -.
DR   InParanoid; Q9FHI7; -.
DR   OMA; LRECLYE; -.
DR   OrthoDB; 1407772at2759; -.
DR   PhylomeDB; Q9FHI7; -.
DR   PRO; PR:Q9FHI7; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   Genevisible; Q9FHI7; AT.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR23155; PTHR23155; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Coiled coil; Nucleotide-binding; Plant defense;
KW   Reference proteome.
FT   CHAIN           1..354
FT                   /note="Probable disease resistance protein At5g45490"
FT                   /id="PRO_0000212767"
FT   DOMAIN          45..122
FT                   /note="NB-ARC"
FT   REGION          328..354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          33..53
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        336..354
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         91..98
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   354 AA;  40426 MW;  F307C25FB55E718C CRC64;
     MPSKNLQQAV LTNEFTTNFI TTCKDWLDVN GLAKGNLEKK RDDNEEEERL KTESKLPGHD
     IHGFDNEIKS LQHFLLDQKV RREFKSLVIV GEYGVGKTAL CQKIFNDEAV KSVYAPRVWV
     SMENKESKEG LDGKICVLKK ILKGLGVEEL ILETISTDAK QEFKDNEEVA SNQEAGEIDR
     ETEKEKELSA LLYALHLNLR WKKYLIVFDD VRENDNWDEK LDAKLKEDEK WGKYLSDGFP
     KGSGGRVIYT TRDENLAKNL VAQKHEIHRL WPLSDHQSVW KIYDAVVKDK QKESPRNDKK
     CIDELMNKSR GLPLAARLLA ERDPVFVDDE VGPVGSTHGQ TDSSNRQPAN QASS