ID   DRL39_ARATH             Reviewed;         623 AA.
AC   Q9LVT1;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Putative disease resistance protein At5g47280;
GN   OrderedLocusNames=At5g47280; ORFNames=MQL5.14;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT   features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:31-63(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
CC   -!- FUNCTION: Potential disease resistance protein. {ECO:0000250}.
CC   -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC       pathogen recognition. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC       of disease resistance gene homologs;
CC       URL="http://niblrrs.ucdavis.edu";
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DR   EMBL; AB018117; BAA97162.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED95493.1; -; Genomic_DNA.
DR   RefSeq; NP_199539.1; NM_124099.1.
DR   AlphaFoldDB; Q9LVT1; -.
DR   SMR; Q9LVT1; -.
DR   STRING; 3702.AT5G47280.1; -.
DR   PaxDb; Q9LVT1; -.
DR   PRIDE; Q9LVT1; -.
DR   EnsemblPlants; AT5G47280.1; AT5G47280.1; AT5G47280.
DR   GeneID; 834775; -.
DR   Gramene; AT5G47280.1; AT5G47280.1; AT5G47280.
DR   KEGG; ath:AT5G47280; -.
DR   Araport; AT5G47280; -.
DR   TAIR; locus:2171479; AT5G47280.
DR   eggNOG; ENOG502QU6E; Eukaryota.
DR   HOGENOM; CLU_012216_1_0_1; -.
DR   InParanoid; Q9LVT1; -.
DR   OMA; YNTTEAT; -.
DR   OrthoDB; 1295759at2759; -.
DR   PhylomeDB; Q9LVT1; -.
DR   PHI-base; PHI:2391; -.
DR   PRO; PR:Q9LVT1; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   Genevisible; Q9LVT1; AT.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.8.430; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR11017; PTHR11017; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Leucine-rich repeat; Nucleotide-binding; Plant defense;
KW   Reference proteome; Repeat.
FT   CHAIN           1..623
FT                   /note="Putative disease resistance protein At5g47280"
FT                   /id="PRO_0000212771"
FT   DOMAIN          2..51
FT                   /note="NB-ARC 1"
FT   DOMAIN          119..249
FT                   /note="NB-ARC 2"
FT   REPEAT          488..511
FT                   /note="LRR 1"
FT   REPEAT          512..534
FT                   /note="LRR 2"
FT   REPEAT          536..558
FT                   /note="LRR 3"
FT   REPEAT          560..581
FT                   /note="LRR 4"
FT   BINDING         16..23
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   623 AA;  70082 MW;  E577CA3BCD266DAE CRC64;
     MLFNLNDEAR IIGISGMIGS GKTILAKELA RDEEVRGHFA NRVLFLTVSQ SPNLEELRSL
     IRDFLTGHEA GFGTALPESV GHTRKLVILD DVRTRESLDQ LMFNIPGTTT LVVSQSKLVD
     PRTTYDVELL NEHDATSLFC LSAFNQKSVP SGFSKSLVKQ VVGESKGLPL SLKVLGASLN
     DRPETYWAIA VERLSRGEPV DETHESKVFA QIEATLENLD PKTKECFLDM GAFPEGKKIP
     VDVLINMLVK IHDLEDAAAF DVLVDLANRN LLTLVKDPTF VAMGTSYYDI FVTQHDVLRD
     VALHLTNRGK VSRRDRLLMP KRETMLPSEW ERSNDEPYNA RVVSIHTGEM TEMDWFDMDF
     PKAEVLIVNF SSDNYVLPPF IAKMGMLRVF VIINNGTSPA HLHDFPIPTS LTNLRSLWLE
     RVHVPELSSS MIPLKNLHKL YLIICKINNS FDQTAIDIAQ IFPKLTDITI DYCDDLAELP
     STICGITSLN SISITNCPNI KELPKNISKL QALQLLRLYA CPELKSLPVE ICELPRLVYV
     DISHCLSLSS LPEKIGNVRT LEKIDMRECS LSSIPSSAVS LTSLCYVTCY REALWMWKEV
     EKAVPGLRIE ATEKWFNMTW PDE