DRL3_ARATH
ID DRL3_ARATH Reviewed; 851 AA.
AC Q9LMP6; F4I187;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 25-JAN-2012, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Probable disease resistance protein At1g15890;
GN OrderedLocusNames=At1g15890; ORFNames=F7H2.22;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Probable disease resistance protein. {ECO:0000250}.
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF82158.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
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DR EMBL; AC034256; AAF82158.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE29380.1; -; Genomic_DNA.
DR PIR; D86293; D86293.
DR RefSeq; NP_173041.1; NM_101457.3.
DR AlphaFoldDB; Q9LMP6; -.
DR SMR; Q9LMP6; -.
DR BioGRID; 23399; 1.
DR STRING; 3702.AT1G15890.1; -.
DR PaxDb; Q9LMP6; -.
DR PRIDE; Q9LMP6; -.
DR ProteomicsDB; 224338; -.
DR EnsemblPlants; AT1G15890.1; AT1G15890.1; AT1G15890.
DR GeneID; 838159; -.
DR Gramene; AT1G15890.1; AT1G15890.1; AT1G15890.
DR KEGG; ath:AT1G15890; -.
DR Araport; AT1G15890; -.
DR TAIR; locus:2036214; AT1G15890.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000427_4_0_1; -.
DR InParanoid; Q9LMP6; -.
DR OMA; CKTTPME; -.
DR OrthoDB; 236715at2759; -.
DR PRO; PR:Q9LMP6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9LMP6; baseline and differential.
DR Genevisible; Q9LMP6; AT.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; Leucine-rich repeat; Nucleotide-binding; Plant defense;
KW Reference proteome; Repeat.
FT CHAIN 1..851
FT /note="Probable disease resistance protein At1g15890"
FT /id="PRO_0000212735"
FT DOMAIN 139..441
FT /note="NB-ARC"
FT REPEAT 514..535
FT /note="LRR 1"
FT REPEAT 536..557
FT /note="LRR 2"
FT REPEAT 560..582
FT /note="LRR 3"
FT REPEAT 584..605
FT /note="LRR 4"
FT REPEAT 607..629
FT /note="LRR 5"
FT BINDING 181..188
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 851 AA; 95845 MW; 938CA0A542283601 CRC64;
MGNCVALEIS CDQTLNHACG CLFGDRNYIL KMEANLEALQ NTMQELEERR DDLLRRVVIE
EDKGLQRLAQ VQGWLSRVKD VCSQVNDLLK AKSIQTERLC LCGYCSKNFI SGRNYGINVL
KKLKHVEGLL AKGVFEVVAE KIPAPKVEKK HIQTTVGLDA MVGRAWNSLM KDERRTLGLY
GMGGVGKTTL LASINNKFLE GMNGFDLVIW VVVSKDLQNE GIQEQILGRL GLHRGWKQVT
EKEKASYICN ILNVKKFVLL LDDLWSEVDL EKIGVPPLTR ENGSKIVFTT RSKDVCRDME
VDGEMKVDCL PPDEAWELFQ KKVGPIPLQS HEDIPTLARK VAEKCCGLPL ALSVIGKAMA
SRETVQEWQH VIHVLNSSSH EFPSMEEKIL PVLKFSYDDL KDEKVKLCFL YCSLFPEDYE
VRKEELIEYW MCEGFIDGNE DEDGANNKGH DIIGSLVRAH LLMDGELTTK VKMHDVIREM
ALWIASNFGK QKETLCVKPG VQLCHIPKDI NWESLRRMSL MCNQIANISS SSNSPNLSTL
LLQNNKLVHI SCDFFRFMPA LVVLDLSRNS SLSSLPEAIS KLGSLQYINL STTGIKWLPV
SFKELKKLIH LNLEFTDELE SIVGIATSLP NLQVLKLFSS RVCIDGSLME ELLLLEHLKV
LTATIKDALI LESIQGVDRL VSSIQALCLR NMSAPVIILN TVALGGLQHL EIVGSKISEI
KIDWERKGRG ELKCTSSPGF KHLSVVEIFN LEGPRDLTWL LFAQNLRRLS VTLSLTIEEI
INKEKGMSIT NVHPNIVVPF GKLEFLEVRG LDELKRICWN PPALPNLRQF DVRSCLKLPE
AATEFPRHAN E
