DRL40_ARATH
ID DRL40_ARATH Reviewed; 888 AA.
AC Q8RXS5; O04666; Q9FM50;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2004, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Probable disease resistance protein At5g63020;
DE AltName: Full=pNd11;
GN OrderedLocusNames=At5g63020; ORFNames=MJH22.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9628582; DOI=10.1093/dnares/5.1.41;
RA Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence
RT features of the regions of 1,456,315 bp covered by nineteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:41-54(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 183-353.
RC STRAIN=cv. Nd-1;
RA Speulman E., Beynon J.;
RT "Disease resistance gene homologous sequence.";
RL Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 302-888.
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- FUNCTION: Probable disease resistance protein. {ECO:0000250}.
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB08845.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
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DR EMBL; AB009051; BAB08845.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED97687.1; -; Genomic_DNA.
DR EMBL; U97223; AAB61688.1; -; Genomic_DNA.
DR EMBL; AY080696; AAL86316.1; -; mRNA.
DR RefSeq; NP_201107.2; NM_125696.4.
DR AlphaFoldDB; Q8RXS5; -.
DR SMR; Q8RXS5; -.
DR STRING; 3702.AT5G63020.1; -.
DR PaxDb; Q8RXS5; -.
DR PRIDE; Q8RXS5; -.
DR ProteomicsDB; 224339; -.
DR EnsemblPlants; AT5G63020.1; AT5G63020.1; AT5G63020.
DR GeneID; 836422; -.
DR Gramene; AT5G63020.1; AT5G63020.1; AT5G63020.
DR KEGG; ath:AT5G63020; -.
DR Araport; AT5G63020; -.
DR TAIR; locus:2166320; AT5G63020.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000427_4_0_1; -.
DR InParanoid; Q8RXS5; -.
DR OMA; SCHEWAL; -.
DR OrthoDB; 236715at2759; -.
DR PhylomeDB; Q8RXS5; -.
DR PRO; PR:Q8RXS5; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8RXS5; baseline and differential.
DR Genevisible; Q8RXS5; AT.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW Plant defense; Reference proteome; Repeat.
FT CHAIN 1..888
FT /note="Probable disease resistance protein At5g63020"
FT /id="PRO_0000212772"
FT DOMAIN 139..442
FT /note="NB-ARC"
FT REPEAT 512..533
FT /note="LRR 1"
FT REPEAT 534..555
FT /note="LRR 2"
FT REPEAT 558..580
FT /note="LRR 3"
FT REPEAT 582..604
FT /note="LRR 4"
FT REPEAT 605..627
FT /note="LRR 5"
FT COILED 22..66
FT /evidence="ECO:0000255"
FT BINDING 181..188
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT CONFLICT 242
FT /note="E -> G (in Ref. 3; AAB61688)"
FT /evidence="ECO:0000305"
FT CONFLICT 338
FT /note="V -> L (in Ref. 3; AAB61688)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 888 AA; 101801 MW; 641FFB321E3238C5 CRC64;
MGGCVSVSIS CDQLTKNVCS CLNRNGDYIH GLEENLTALQ RALEQIEQRR EDLLRKILSE
ERRGLQRLSV VQGWVSKVEA IVPRVNELVR MRSVQVQRLC LCGFCSKNLV SSYRYGKRVM
KMIEEVEVLR YQGDFAVVAE RVDAARVEER PTRPMVAMDP MLESAWNRLM EDEIGILGLH
GMGGVGKTTL LSHINNRFSR VGGEFDIVIW IVVSKELQIQ RIQDEIWEKL RSDNEKWKQK
TEDIKASNIY NVLKHKRFVL LLDDIWSKVD LTEVGVPFPS RENGCKIVFT TRLKEICGRM
GVDSDMEVRC LAPDDAWDLF TKKVGEITLG SHPEIPTVAR TVAKKCRGLP LALNVIGETM
AYKRTVQEWR SAIDVLTSSA AEFSGMEDEI LPILKYSYDN LKSEQLKLCF QYCALFPEDH
NIEKNDLVDY WIGEGFIDRN KGKAENQGYE IIGILVRSCL LMEENQETVK MHDVVREMAL
WIASDFGKQK ENFIVQAGLQ SRNIPEIEKW KVARRVSLMF NNIESIRDAP ESPQLITLLL
RKNFLGHISS SFFRLMPMLV VLDLSMNRDL RHLPNEISEC VSLQYLSLSR TRIRIWPAGL
VELRKLLYLN LEYTRMVESI CGISGLTSLK VLRLFVSGFP EDPCVLNELQ LLENLQTLTI
TLGLASILEQ FLSNQRLASC TRALRIENLN PQSSVISFVA TMDSLQELHF ADSDIWEIKV
KRNETVLPLH IPTTTTFFPN LSQVSLEFCT RLRDLTWLIF APNLTVLRVI SASDLKEVIN
KEKAEQQNLI PFQELKELRL ENVQMLKHIH RGPLPFPCLQ KILVNGCSEL RKLPLNFTSV
PRGDLVIEAH KKWIEILEWE DEATKARFLP TLKAFPENID ADGYEISF
