ID   DRL41_ARATH             Reviewed;         415 AA.
AC   Q9FKZ2;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Probable disease resistance protein At5g66890;
GN   OrderedLocusNames=At5g66890; ORFNames=MUD21.15;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA   Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT   features of the regions of 1,381,565 bp covered by twenty one physically
RT   assigned P1 and TAC clones.";
RL   DNA Res. 5:131-145(1998).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
CC   -!- FUNCTION: Possible disease resistance protein. {ECO:0000250}.
CC   -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC       pathogen recognition. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Lacks the typical ATP binding site, suggesting that it may not
CC       be functional. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC       of disease resistance gene homologs;
CC       URL="http://niblrrs.ucdavis.edu";
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DR   EMBL; AB010700; BAB08631.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED98275.1; -; Genomic_DNA.
DR   RefSeq; NP_201490.1; NM_126088.2.
DR   AlphaFoldDB; Q9FKZ2; -.
DR   SMR; Q9FKZ2; -.
DR   STRING; 3702.AT5G66890.1; -.
DR   PaxDb; Q9FKZ2; -.
DR   PRIDE; Q9FKZ2; -.
DR   EnsemblPlants; AT5G66890.1; AT5G66890.1; AT5G66890.
DR   GeneID; 836823; -.
DR   Gramene; AT5G66890.1; AT5G66890.1; AT5G66890.
DR   KEGG; ath:AT5G66890; -.
DR   Araport; AT5G66890; -.
DR   TAIR; locus:2175009; AT5G66890.
DR   eggNOG; ENOG502QSSA; Eukaryota.
DR   HOGENOM; CLU_012216_1_0_1; -.
DR   InParanoid; Q9FKZ2; -.
DR   OMA; HQWEKES; -.
DR   OrthoDB; 259913at2759; -.
DR   PhylomeDB; Q9FKZ2; -.
DR   PRO; PR:Q9FKZ2; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FKZ2; baseline and differential.
DR   Genevisible; Q9FKZ2; AT.
DR   GO; GO:0050832; P:defense response to fungus; IEA:InterPro.
DR   GO; GO:0098542; P:defense response to other organism; IGI:TAIR.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR039203; RPW8-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR36766; PTHR36766; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Leucine-rich repeat; Plant defense; Reference proteome;
KW   Repeat.
FT   CHAIN           1..415
FT                   /note="Probable disease resistance protein At5g66890"
FT                   /id="PRO_0000212773"
FT   DOMAIN          8..43
FT                   /note="NB-ARC"
FT   REPEAT          229..251
FT                   /note="LRR 1"
FT   REPEAT          256..278
FT                   /note="LRR 2"
FT   REPEAT          280..303
FT                   /note="LRR 3"
FT   REPEAT          304..326
FT                   /note="LRR 4"
FT   REPEAT          328..351
FT                   /note="LRR 5"
FT   REPEAT          352..373
FT                   /note="LRR 6"
FT   COILED          239..260
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   415 AA;  47554 MW;  3C77B5F97E01C70B CRC64;
     MNSNSIQSFD ALPHNLRECF LDMASFLEDQ RIIASTIIDL WSASYGKEGM NNLQDLASRN
     LLKLLPIGRN EYEDGFYNEL LVKQDNVLRE FAINQCLKES SSIFERKRLN LEIQDNKFPN
     WCLNPKQPIV INASLFSIST DDSFASSWFE MDCPNVEALV LNISSSNYAL PNFIATMKEL
     KVVIIINHGL EPAKLTNLSC LSSLPNLKRI RFEKVSISLL DIPKLGLKSL EKLSLWFCHV
     VDALNELEDV SETLQSLQEI EIDYCYNLDE LPYWISQVVS LKKLSVTNCN KLCRVIEAIG
     DLRDLETLRL SSCASLLELP ETIDRLDNLR FLDVSGGFQL KNLPLEIGKL KKLEKISMKD
     CYRCELPDSV KNLENLEVKC DEDTAFLWKI LKPEMKNLTI TEEKTEHNLN LLQLF