DRL42_ARATH
ID DRL42_ARATH Reviewed; 809 AA.
AC Q9FKZ1;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Probable disease resistance protein At5g66900;
GN OrderedLocusNames=At5g66900; ORFNames=MUD21.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT features of the regions of 1,381,565 bp covered by twenty one physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:131-145(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Probable disease resistance protein. {ECO:0000250}.
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
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DR EMBL; AB010700; BAB08632.1; -; Genomic_DNA.
DR EMBL; CP002688; AED98276.1; -; Genomic_DNA.
DR RefSeq; NP_201491.1; NM_126089.3.
DR PDB; 7L7V; X-ray; 2.95 A; A/B/C/D/E/F=1-124.
DR PDB; 7L7W; X-ray; 2.55 A; A=1-124.
DR PDBsum; 7L7V; -.
DR PDBsum; 7L7W; -.
DR AlphaFoldDB; Q9FKZ1; -.
DR SMR; Q9FKZ1; -.
DR STRING; 3702.AT5G66900.1; -.
DR PaxDb; Q9FKZ1; -.
DR PRIDE; Q9FKZ1; -.
DR EnsemblPlants; AT5G66900.1; AT5G66900.1; AT5G66900.
DR GeneID; 836824; -.
DR Gramene; AT5G66900.1; AT5G66900.1; AT5G66900.
DR KEGG; ath:AT5G66900; -.
DR Araport; AT5G66900; -.
DR TAIR; locus:2175019; AT5G66900.
DR eggNOG; ENOG502QSSA; Eukaryota.
DR HOGENOM; CLU_012216_0_0_1; -.
DR InParanoid; Q9FKZ1; -.
DR PhylomeDB; Q9FKZ1; -.
DR PRO; PR:Q9FKZ1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FKZ1; baseline and differential.
DR Genevisible; Q9FKZ1; AT.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0012505; C:endomembrane system; IDA:TAIR.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR GO; GO:0050832; P:defense response to fungus; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008808; Powdery_mildew-R_dom.
DR InterPro; IPR039203; RPW8-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR36766; PTHR36766; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF05659; RPW8; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51153; RPW8; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ATP-binding; Coiled coil; Leucine-rich repeat;
KW Nucleotide-binding; Plant defense; Reference proteome; Repeat.
FT CHAIN 1..809
FT /note="Probable disease resistance protein At5g66900"
FT /id="PRO_0000212774"
FT DOMAIN 1..150
FT /note="RPW8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00495"
FT DOMAIN 153..280
FT /note="NB-ARC 1"
FT DOMAIN 339..438
FT /note="NB-ARC 2"
FT REPEAT 650..672
FT /note="LRR 1"
FT REPEAT 674..696
FT /note="LRR 2"
FT REPEAT 698..720
FT /note="LRR 3"
FT REPEAT 722..744
FT /note="LRR 4"
FT COILED 50..86
FT /evidence="ECO:0000255"
FT COILED 494..515
FT /evidence="ECO:0000255"
FT BINDING 194..201
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT HELIX 1..6
FT /evidence="ECO:0007829|PDB:7L7V"
FT STRAND 11..15
FT /evidence="ECO:0007829|PDB:7L7V"
FT HELIX 17..29
FT /evidence="ECO:0007829|PDB:7L7W"
FT HELIX 35..38
FT /evidence="ECO:0007829|PDB:7L7W"
FT HELIX 40..57
FT /evidence="ECO:0007829|PDB:7L7W"
FT TURN 58..61
FT /evidence="ECO:0007829|PDB:7L7W"
FT STRAND 64..66
FT /evidence="ECO:0007829|PDB:7L7V"
FT HELIX 67..85
FT /evidence="ECO:0007829|PDB:7L7W"
FT HELIX 86..88
FT /evidence="ECO:0007829|PDB:7L7W"
FT HELIX 91..93
FT /evidence="ECO:0007829|PDB:7L7W"
FT HELIX 94..111
FT /evidence="ECO:0007829|PDB:7L7W"
FT HELIX 116..124
FT /evidence="ECO:0007829|PDB:7L7W"
SQ SEQUENCE 809 AA; 92245 MW; 6227C847272F3B7E CRC64;
MNDWASLGIG SIGEAVFSKL LKVVIDEAKK FKAFKPLSKD LVSTMEILFP LTQKIDSMQK
ELDFGVKELK ELRDTIERAD VAVRKFPRVK WYEKSKYTRK IERINKDMLK FCQIDLQLLQ
HRNQLTLLGL TGNLVNSVDG LSKRMDLLSV PAPVFRDLCS VPKLDKVIVG LDWPLGELKK
RLLDDSVVTL VVSAPPGCGK TTLVSRLCDD PDIKGKFKHI FFNVVSNTPN FRVIVQNLLQ
HNGYNALTFE NDSQAEVGLR KLLEELKENG PILLVLDDVW RGADSFLQKF QIKLPNYKIL
VTSRFDFPSF DSNYRLKPLE DDDARALLIH WASRPCNTSP DEYEDLLQKI LKRCNGFPIV
IEVVGVSLKG RSLNTWKGQV ESWSEGEKIL GKPYPTVLEC LQPSFDALDP NLKECFLDMG
SFLEDQKIRA SVIIDMWVEL YGKGSSILYM YLEDLASQNL LKLVPLGTNE HEDGFYNDFL
VTQHDILREL AICQSEFKEN LERKRLNLEI LENTFPDWCL NTINASLLSI STDDLFSSKW
LEMDCPNVEA LVLNLSSSDY ALPSFISGMK KLKVLTITNH GFYPARLSNF SCLSSLPNLK
RIRLEKVSIT LLDIPQLQLS SLKKLSLVMC SFGEVFYDTE DIVVSNALSK LQEIDIDYCY
DLDELPYWIS EIVSLKTLSI TNCNKLSQLP EAIGNLSRLE VLRLCSSMNL SELPEATEGL
SNLRFLDISH CLGLRKLPQE IGKLQNLKKI SMRKCSGCEL PESVTNLENL EVKCDEETGL
LWERLKPKMR NLRVQEEEIE HNLNLLQMF
