DRL43_ARATH
ID DRL43_ARATH Reviewed; 815 AA.
AC Q9FKZ0;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Probable disease resistance protein At5g66910;
GN OrderedLocusNames=At5g66910; ORFNames=MUD21.17;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT features of the regions of 1,381,565 bp covered by twenty one physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:131-145(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- FUNCTION: Probable disease resistance protein. {ECO:0000250}.
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
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DR EMBL; AB010700; BAB08633.1; -; Genomic_DNA.
DR EMBL; CP002688; AED98277.1; -; Genomic_DNA.
DR EMBL; AF462802; AAL58897.1; -; mRNA.
DR RefSeq; NP_201492.1; NM_126090.5.
DR AlphaFoldDB; Q9FKZ0; -.
DR SMR; Q9FKZ0; -.
DR STRING; 3702.AT5G66910.1; -.
DR iPTMnet; Q9FKZ0; -.
DR PaxDb; Q9FKZ0; -.
DR PRIDE; Q9FKZ0; -.
DR ProteomicsDB; 224342; -.
DR EnsemblPlants; AT5G66910.1; AT5G66910.1; AT5G66910.
DR GeneID; 836825; -.
DR Gramene; AT5G66910.1; AT5G66910.1; AT5G66910.
DR KEGG; ath:AT5G66910; -.
DR Araport; AT5G66910; -.
DR TAIR; locus:2174944; AT5G66910.
DR eggNOG; ENOG502QSSA; Eukaryota.
DR HOGENOM; CLU_012216_0_0_1; -.
DR InParanoid; Q9FKZ0; -.
DR OMA; FWSIANI; -.
DR OrthoDB; 259913at2759; -.
DR PhylomeDB; Q9FKZ0; -.
DR PRO; PR:Q9FKZ0; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FKZ0; baseline and differential.
DR Genevisible; Q9FKZ0; AT.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0012505; C:endomembrane system; IDA:TAIR.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR GO; GO:0050832; P:defense response to fungus; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008808; Powdery_mildew-R_dom.
DR InterPro; IPR039203; RPW8-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR36766; PTHR36766; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF05659; RPW8; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51153; RPW8; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Leucine-rich repeat; Nucleotide-binding; Plant defense;
KW Reference proteome; Repeat.
FT CHAIN 1..815
FT /note="Probable disease resistance protein At5g66910"
FT /id="PRO_0000212775"
FT DOMAIN 1..150
FT /note="RPW8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00495"
FT DOMAIN 156..283
FT /note="NB-ARC 1"
FT DOMAIN 341..440
FT /note="NB-ARC 2"
FT REPEAT 656..678
FT /note="LRR 1"
FT REPEAT 680..702
FT /note="LRR 2"
FT REPEAT 704..726
FT /note="LRR 3"
FT REPEAT 728..750
FT /note="LRR 4"
FT BINDING 196..203
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 815 AA; 92930 MW; 0513D07FDC274A66 CRC64;
MVVVDWLGLG LGSVAGALVS EGLKVLISEA KKVLAFKSVS NELASTMESL LPVIKEIESM
QDGMELQDLK DTIDKALLLV EKCSHVEKWN IILKSKYTRK VEEINRKMLK FCQVQLQLLL
FRNQLKSMPS MEAILNNYFQ NINKKLDRLS GSPAPPLVSK RCSVPKLDNM VLVGLDWPLV
ELKKKLLDNS VVVVSGPPGC GKTTLVTKLC DDPEIEGEFK KIFYSVVSNT PNFRAIVQNL
LQDNGCGAIT FDDDSQAETG LRDLLEELTK DGRILLVLDD VWQGSEFLLR KFQIDLPDYK
ILVTSQFDFT SLWPTYHLVP LKYEYARSLL IQWASPPLHT SPDEYEDLLQ KILKRCNGFP
LVIEVVGISL KGQALYLWKG QVESWSEGET ILGNANPTVR QRLQPSFNVL KPHLKECFMD
MGSFLQDQKI RASLIIDIWM ELYGRGSSST NKFMLYLNEL ASQNLLKLVH LGTNKREDGF
YNELLVTQHN ILRELAIFQS ELEPIMQRKK LNLEIREDNF PDECLNQPIN ARLLSIYTDD
LFSSKWLEMD CPNVEALVLN ISSLDYALPS FIAEMKKLKV LTIANHGFYP ARLSNFSCLS
SLPNLKRIRF EKVSVTLLDI PQLQLGSLKK LSFFMCSFGE VFYDTEDIDV SKALSNLQEI
DIDYCYDLDE LPYWIPEVVS LKTLSITNCN KLSQLPEAIG NLSRLEVLRM CSCMNLSELP
EATERLSNLR SLDISHCLGL RKLPQEIGKL QKLENISMRK CSGCELPDSV RYLENLEVKC
DEVTGLLWER LMPEMRNLRV HTEETEHNLK LLLTF
