DRL45_ARATH
ID DRL45_ARATH Reviewed; 1049 AA.
AC P0DI18; Q94HW3; Q94HW8; Q9SLU7; Q9SLU8;
DT 16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2012, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Probable disease resistance protein RDL6;
GN Name=RDL6; OrderedLocusNames=At1g59218; ORFNames=T4M14.7;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Potential disease resistance protein.
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
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DR EMBL; AC027036; AAK62782.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33573.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33574.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60966.1; -; Genomic_DNA.
DR RefSeq; NP_001031207.1; NM_001036130.2.
DR RefSeq; NP_001185265.1; NM_001198336.2.
DR RefSeq; NP_001323213.1; NM_001333848.1.
DR RefSeq; NP_176153.1; NM_104637.4.
DR RefSeq; NP_683447.2; NM_148606.3.
DR AlphaFoldDB; P0DI18; -.
DR SMR; P0DI18; -.
DR EnsemblPlants; AT1G58848.1; AT1G58848.1; AT1G58848.
DR EnsemblPlants; AT1G58848.2; AT1G58848.2; AT1G58848.
DR EnsemblPlants; AT1G59218.1; AT1G59218.1; AT1G59218.
DR EnsemblPlants; AT1G59218.2; AT1G59218.2; AT1G59218.
DR EnsemblPlants; AT1G59218.3; AT1G59218.3; AT1G59218.
DR GeneID; 842226; -.
DR GeneID; 842234; -.
DR Gramene; AT1G58848.1; AT1G58848.1; AT1G58848.
DR Gramene; AT1G58848.2; AT1G58848.2; AT1G58848.
DR Gramene; AT1G59218.1; AT1G59218.1; AT1G59218.
DR Gramene; AT1G59218.2; AT1G59218.2; AT1G59218.
DR Gramene; AT1G59218.3; AT1G59218.3; AT1G59218.
DR KEGG; ath:AT1G58848; -.
DR KEGG; ath:AT1G59218; -.
DR Araport; AT1G59218; -.
DR HOGENOM; CLU_000837_35_5_1; -.
DR InParanoid; P0DI18; -.
DR OMA; GINICFT; -.
DR OrthoDB; 164862at2759; -.
DR PhylomeDB; P0DI18; -.
DR PRO; PR:P0DI18; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; P0DI18; baseline and differential.
DR Genevisible; P0DI18; AT.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW Plant defense; Reference proteome; Repeat.
FT CHAIN 1..1049
FT /note="Probable disease resistance protein RDL6"
FT /id="PRO_0000417494"
FT DOMAIN 147..460
FT /note="NB-ARC"
FT REPEAT 584..608
FT /note="LRR 1"
FT REPEAT 609..634
FT /note="LRR 2"
FT REPEAT 657..682
FT /note="LRR 3"
FT REPEAT 683..707
FT /note="LRR 4"
FT REPEAT 776..799
FT /note="LRR 5"
FT REPEAT 800..827
FT /note="LRR 6"
FT REPEAT 849..873
FT /note="LRR 7"
FT REPEAT 896..923
FT /note="LRR 8"
FT REPEAT 945..968
FT /note="LRR 9"
FT REPEAT 990..1015
FT /note="LRR 10"
FT REGION 139..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 25..41
FT /evidence="ECO:0000255"
FT COMPBIAS 143..158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 190..197
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1049 AA; 121045 MW; 0F0B6ABDEEBABBB6 CRC64;
MAGELISFGI QNLWNLLSQE CELFQGVEDQ VTELKRDLNL LSSFLKDADA KKHTSAVVKN
CVEEIKEIIY DGEDTIETFV LEQNLGKTSG IKKSIRRLAC IIPDRRRYAL GIGGLSNRIS
KVIRDMQSFG VQQAIVDGGY KQPQGDKQRE MRPRFSKDDD SDFVGLEANV KKLVGYLVDE
ANVQVVSITG MGGLGKTTLA KQVFNHEDVK HQFDGLSWVC VSQDFTRMNV WQKILRDLKP
KEEEKKIMEM TQDTLQGELI RLLETSKSLI VLDDIWEKED WELIKPIFPP TKGWKVLLTS
RNESVAMRRN TSYINFKPEC LTTEDSWTLF QRIALPMKDA AEFKIDEEKE ELGKLMIKHC
GGLPLAIRVL GGMLAEKYTS HDWRRLSENI GSHLVGGRTN FNDDNNNTCN YVLSLSFEEL
PSYLKHCFLY LAHFPDDYEI NVKNLSYYWA AEGIFQPRHY DGEIIRDVGD VYIEELVRRN
MVISERDVKT SRFETCHLHD MMREVCLLKA KEENFLQITS SRTSTGNSLS IVTSRRLVYQ
YPITLDVEKD INDPKLRSLV VVANTYMFWG GWSWMLLGSS FIRLELLRVL DIHRAKLKGG
KLASSIGQLI HLRYLNLKHA EVTHIPYSLG NLKLLIYLNL VILVSGSTLV PNVLKEMQQL
RYLALPKDMG RKTKLELSNL VKLETLKNFS TKNCSLEDLR GMVRLRTLTI ELRKETSLET
LAASIGGLKY LESLTITDLG SEMRTKEAGI VFDFVYLKTL TLKLYMPRLS KEQHFPSHLT
TLYLQHCRLE EDPMPILEKL HQLKELELRR KSFSGKEMVC SSGGFPQLQK LSIKGLEEWE
DWKVEESSMP VLHTLDIRDC RKLKQLPDEH LPSHLTSISL FFCCLEEDPM PTLERLVHLK
ELQLLFRSFS GRIMVCAGSG FPQLHKLKLS ELDGLEEWIV EDGSMPQLHT LEIRRCPKLK
KLPNGFPQLQ NLELNELEEW EEWIVEDGSM PLLHTLRIWN CPKLKQLPDG LRFIYSLKNL
TVPKRWKKRL SKGGEDYYKV QHIPSVEFY
