DRL4_ARATH
ID DRL4_ARATH Reviewed; 857 AA.
AC Q9SX38; F4I4Y9;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 25-JAN-2012, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Putative disease resistance protein At1g50180;
GN OrderedLocusNames=At1g50180; ORFNames=F14I3.19;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Potential disease resistance protein. {ECO:0000250}.
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD50046.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC007980; AAD50046.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE32522.1; -; Genomic_DNA.
DR PIR; B96538; B96538.
DR RefSeq; NP_175437.1; NM_103903.2.
DR AlphaFoldDB; Q9SX38; -.
DR SMR; Q9SX38; -.
DR BioGRID; 26665; 1.
DR STRING; 3702.AT1G50180.1; -.
DR PaxDb; Q9SX38; -.
DR PRIDE; Q9SX38; -.
DR EnsemblPlants; AT1G50180.1; AT1G50180.1; AT1G50180.
DR GeneID; 841440; -.
DR Gramene; AT1G50180.1; AT1G50180.1; AT1G50180.
DR KEGG; ath:AT1G50180; -.
DR Araport; AT1G50180; -.
DR TAIR; locus:2011982; AT1G50180.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000837_25_4_1; -.
DR InParanoid; Q9SX38; -.
DR OMA; CEESWEL; -.
DR OrthoDB; 164862at2759; -.
DR PRO; PR:Q9SX38; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SX38; baseline and differential.
DR Genevisible; Q9SX38; AT.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW Plant defense; Reference proteome; Repeat.
FT CHAIN 1..857
FT /note="Putative disease resistance protein At1g50180"
FT /id="PRO_0000212736"
FT DOMAIN 148..461
FT /note="NB-ARC"
FT REPEAT 653..678
FT /note="LRR 1"
FT REPEAT 680..703
FT /note="LRR 2"
FT REPEAT 754..780
FT /note="LRR 3"
FT REPEAT 791..816
FT /note="LRR 4"
FT COILED 27..60
FT /evidence="ECO:0000255"
FT BINDING 192..199
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 857 AA; 97275 MW; 94FDD7BD2D411E2B CRC64;
MAEAIVSVTV QKLGQLLLEE PLFLFGIGDQ VKQLQDELKR LNCFLKDADE KQHESERVRN
WVAGIREASY DAEDILEAFF LKAESRKQKG MKRVLRRLAC ILNEAVSLHS VGSEIREITS
RLSKIAASML DFGIKESMGR EGLSLSDSLR EQRQSFPYVV EHNLVGLEQS LEKLVNDLVS
GGEKLRVTSI CGMGGLGKTT LAKQIFHHHK VRRHFDRFAW VYVSQDCRRR HVWQDIFLNL
SYKDENQRIL SLRDEQLGEE LHRFLKRNKC LIVLDDIWGK DAWDCLKHVF PHETGSEIIL
TTRNKEVALY ADPRGVLHEP QLLTCEESWE LLEKISLSGR ENIEPMLVKK MEEIGKQIVV
RCGGLPLAIT VLGGLLATKS TWNEWQRVCE NIKSYVSNGG SSNGSKNMLV ADVLCLSYEY
LPPHVKQCFL YFAHYPEDYE VHVGTLVSYC IAEGMVMPVK HTEAGTTVED VGQDYLEELV
KRSMVMVGRR DIVTSEVMTC RMHDLMREVC LQKAKQESFV QVIDSRDQDE AEAFISLSTN
TSRRISVQLH GGAEEHHIKS LSQVSFRKMK LLRVLDLEGA QIEGGKLPDD VGDLIHLRNL
SVRLTNVKEL TSSIGNLKLM ITLDLFVKGQ LYIPNQLWDF PVGKCNPRDL LAMTSLRRLS
INLSSQNTDF VVVSSLSKVL KRLRGLTINV PCEPMLPPVD VTQLVSAFTN LCELELFLKL
EKLPGEQSFS SDLGALRLWQ CGLVDDPFMV LEKLPNLKIL QLFEGSFVGS KLCCSKNLEN
LEEWTVEDGA MMRLVTVELK CCNKLKSVPE GTRFLKNLQE VEIGNRTKAF KDKLISGGED
FYKVQHVPCV VFENCEL
