DRL5_ARATH
ID DRL5_ARATH Reviewed; 854 AA.
AC Q9C8K0; F4I9J4;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2004, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Probable disease resistance protein At1g51480;
GN OrderedLocusNames=At1g51480; ORFNames=F5D21.7;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Probable disease resistance protein. {ECO:0000250}.
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG52625.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
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DR EMBL; AC024261; AAG52625.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE32672.2; -; Genomic_DNA.
DR PIR; B96553; B96553.
DR RefSeq; NP_175559.2; NM_104026.2.
DR AlphaFoldDB; Q9C8K0; -.
DR SMR; Q9C8K0; -.
DR STRING; 3702.AT1G51480.1; -.
DR PaxDb; Q9C8K0; -.
DR PRIDE; Q9C8K0; -.
DR EnsemblPlants; AT1G51480.1; AT1G51480.1; AT1G51480.
DR GeneID; 841573; -.
DR Gramene; AT1G51480.1; AT1G51480.1; AT1G51480.
DR KEGG; ath:AT1G51480; -.
DR Araport; AT1G51480; -.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000427_4_0_1; -.
DR InParanoid; Q9C8K0; -.
DR OMA; DWIIGYC; -.
DR OrthoDB; 169620at2759; -.
DR PhylomeDB; Q9C8K0; -.
DR PRO; PR:Q9C8K0; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C8K0; baseline and differential.
DR Genevisible; Q9C8K0; AT.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW Plant defense; Reference proteome; Repeat.
FT CHAIN 1..854
FT /note="Probable disease resistance protein At1g51480"
FT /id="PRO_0000212737"
FT DOMAIN 138..441
FT /note="NB-ARC"
FT REPEAT 514..535
FT /note="LRR 1"
FT REPEAT 536..557
FT /note="LRR 2"
FT REPEAT 560..582
FT /note="LRR 3"
FT REPEAT 584..605
FT /note="LRR 4"
FT REPEAT 607..629
FT /note="LRR 5"
FT REPEAT 631..652
FT /note="LRR 6"
FT COILED 25..62
FT /evidence="ECO:0000255"
FT BINDING 180..187
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 854 AA; 97307 MW; 2D440142AEA5370D CRC64;
MADWLLLIPW NKIFTAACGC FFSDRNYIHK MEANLDDLHT TMEELKNGRD DLLRRVSIEE
DKGLQQLAQV KGWISRVEIV ESRFKDLLED KSTETGRLCL FGFCSENCIS SYNYGEKVMK
NLEEVKELLS KKHFEVVAHK IPVPKVEEKN IHTTVGLYAM VEMAWKSLMN DEIRTLCLHG
MGGVGKTTLL ACINNKFVEL ESEFDVVIWV VVSKDFQLEG IQDQILGRLR LDKEWERETE
NKKASLINNN LKRKKFVLLL DDLWSEVDLN KIGVPPPTRE NGAKIVFTKR SKEVSKYMKA
DMQIKVSCLS PDEAWELFRI TVDDVILSSH EDIPALARIV AAKCHGLPLA LIVIGEAMAC
KETIQEWHHA INVLNSPAGH KFPGMEERIL LVLKFSYDSL KNGEIKLCFL YCSLFPEDFE
IEKEKLIEYW ICEGYINPNR YEDGGTNQGY DIIGLLVRAH LLIECELTTK VKMHYVIREM
ALWINSDFGK QQETICVKSG AHVRMIPNDI NWEIVRQVSL ISTQIEKISC SSKCSNLSTL
LLPYNKLVNI SVGFFLFMPK LVVLDLSTNM SLIELPEEIS NLCSLQYLNL SSTGIKSLPG
GMKKLRKLIY LNLEFSYKLE SLVGISATLP NLQVLKLFYS NVCVDDILME ELQHMDHLKI
LTVTIDDAMI LERIQGIDRL ASSIRGLCLT NMSAPRVVLS TTALGGLQQL AILSCNISEI
KMDWKSKERR EVSPMEIHPS TSTSSPGFKQ LSSVNIMKLV GPRDLSWLLF AQNLKSLHVG
FSPEIEEIIN KEKGSSITKE IAFGKLESLV IYKLPELKEI CWNYRTLPNS RYFDVKDCPK
LPEDIANFPM HAEE
