ID   DRL6_ARATH              Reviewed;         375 AA.
AC   Q9SSR8; F4IEJ2;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Probable disease resistance protein At1g52660;
GN   OrderedLocusNames=At1g52660; ORFNames=F6D8.12;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
CC   -!- FUNCTION: Possible disease resistance protein. {ECO:0000250}.
CC   -!- CAUTION: Although strongly related to the NB-LRR family, it is shorter
CC       and lacks the LRR repeats that are present in other proteins of the
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AEE32835.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC       of disease resistance gene homologs;
CC       URL="http://niblrrs.ucdavis.edu";
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DR   EMBL; AC008016; AAD55599.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE32835.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; ANM58115.1; -; Genomic_DNA.
DR   PIR; E96567; E96567.
DR   RefSeq; NP_001320574.1; NM_001333556.1.
DR   RefSeq; NP_175675.4; NM_104144.5.
DR   AlphaFoldDB; Q9SSR8; -.
DR   SMR; Q9SSR8; -.
DR   STRING; 3702.AT1G52660.1; -.
DR   MetOSite; Q9SSR8; -.
DR   PaxDb; Q9SSR8; -.
DR   PRIDE; Q9SSR8; -.
DR   EnsemblPlants; AT1G52660.2; AT1G52660.2; AT1G52660.
DR   GeneID; 841698; -.
DR   Gramene; AT1G52660.2; AT1G52660.2; AT1G52660.
DR   KEGG; ath:AT1G52660; -.
DR   Araport; AT1G52660; -.
DR   eggNOG; KOG4658; Eukaryota.
DR   HOGENOM; CLU_000427_1_2_1; -.
DR   InParanoid; Q9SSR8; -.
DR   OMA; AFDPIIW; -.
DR   OrthoDB; 169620at2759; -.
DR   PhylomeDB; Q9SSR8; -.
DR   PRO; PR:Q9SSR8; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9SSR8; baseline and differential.
DR   Genevisible; Q9SSR8; AT.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.8.430; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR23155; PTHR23155; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Nucleotide-binding; Plant defense; Reference proteome.
FT   CHAIN           1..375
FT                   /note="Probable disease resistance protein At1g52660"
FT                   /id="PRO_0000212738"
FT   DOMAIN          158..372
FT                   /note="NB-ARC"
FT   BINDING         167..174
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   375 AA;  41896 MW;  9D507FA7BF8ACA58 CRC64;
     MGKDFKSLVT RCIYVGKMND NAKKLKIATE ELKDLGNNVM KRVKLCEEQQ QMKRLDKVQT
     WLRQADTVIK EAEEYFLMSS SSSSSGLISS SHKMEKKICK KLKEVQEIKS RGMFEVVAES
     TGGIGGGAGG GLTIKDSDEQ TIGLEAVSGL VWRCLTMENT GIIGLYGVEG VGKTTVLTQV
     NNRLLQQKAN GFDFVLWVFV SKNLNLQKIQ DTIREKIGFL DRTWTSKSEE EKAAKIFEIL
     SKRRFALFLD DVWEKVDLVK AGVPPPDAQN RSKIVFTTCS EEVCKEMSAQ TKIKVEKLAW
     ERAWDLFKKN VGEDTIKSHP DIAKVAQEVA ARCDGLPLAL VTIGRAMASK KTPQEWRDAL
     YILSNSPPNF SGQIS