DRL7_ARATH
ID DRL7_ARATH Reviewed; 907 AA.
AC Q8W474; F4IBC6; Q9C644; Q9SM05;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 25-JAN-2012, sequence version 4.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Probable disease resistance protein At1g58390;
GN OrderedLocusNames=At1g58390; ORFNames=F9K23.8, X7J.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NUCLEOTIDE SEQUENCE [MRNA] OF 1-592.
RC STRAIN=cv. Columbia;
RX PubMed=10548732; DOI=10.1016/s0378-1119(99)00403-5;
RA Kato A., Suzuki M., Kuwahara A., Ooe H., Higano-Inaba K., Komeda Y.;
RT "Isolation and analysis of cDNA within a 300 kb Arabidopsis thaliana
RT genomic region located around the 100 map unit of chromosome 1.";
RL Gene 239:309-316(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-586.
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- FUNCTION: Possible disease resistance protein.
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL32876.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAA88265.1; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
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DR EMBL; AB008018; BAA88265.1; ALT_SEQ; mRNA.
DR EMBL; AB077822; BAB83871.1; -; Genomic_DNA.
DR EMBL; AC082643; AAG50638.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33544.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60615.1; -; Genomic_DNA.
DR EMBL; AY062798; AAL32876.1; ALT_INIT; mRNA.
DR PIR; F96617; F96617.
DR PIR; T52465; T52465.
DR RefSeq; NP_001319265.1; NM_001333830.1.
DR RefSeq; NP_176135.1; NM_104619.3.
DR AlphaFoldDB; Q8W474; -.
DR SMR; Q8W474; -.
DR BioGRID; 27433; 1.
DR STRING; 3702.AT1G58390.1; -.
DR iPTMnet; Q8W474; -.
DR PaxDb; Q8W474; -.
DR PRIDE; Q8W474; -.
DR ProteomicsDB; 224348; -.
DR EnsemblPlants; AT1G58390.1; AT1G58390.1; AT1G58390.
DR EnsemblPlants; AT1G58390.2; AT1G58390.2; AT1G58390.
DR GeneID; 842208; -.
DR Gramene; AT1G58390.1; AT1G58390.1; AT1G58390.
DR Gramene; AT1G58390.2; AT1G58390.2; AT1G58390.
DR KEGG; ath:AT1G58390; -.
DR Araport; AT1G58390; -.
DR TAIR; locus:2037639; AT1G58390.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000837_25_4_1; -.
DR InParanoid; Q8W474; -.
DR OMA; YHVLSMS; -.
DR OrthoDB; 164862at2759; -.
DR PRO; PR:Q8W474; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8W474; baseline and differential.
DR Genevisible; Q8W474; AT.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Leucine-rich repeat; Nucleotide-binding; Plant defense;
KW Reference proteome; Repeat.
FT CHAIN 1..907
FT /note="Probable disease resistance protein At1g58390"
FT /id="PRO_0000212739"
FT DOMAIN 144..456
FT /note="NB-ARC"
FT REPEAT 608..631
FT /note="LRR 1"
FT REPEAT 843..868
FT /note="LRR 2"
FT BINDING 190..197
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT CONFLICT 587
FT /note="R -> K (in Ref. 1; BAA88265)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 907 AA; 104596 MW; 4CA13E4F7A1DF7BA CRC64;
MAGELVSFGI KKLWDLLSQE CEQFQGVEDQ VTGLKRDLNL LSSFLKDADA KKHTTAVVRN
VVEEIKEIVY DAEDIIETYL LKEKLWKTSG IKMRIRRHAC IISDRRRNAL DVGGIRTRIS
DVIRDMQSFG VQQAIVDGGY MQPQGDRQRE MRQTFSKDYE SDFVGLEVNV KKLVGYLVDE
ENVQVVSITG MGGLGKTTLA RQVFNHEDVK HQFDRLAWVC VSQEFTRKNV WQMILQNLTS
REKKDEILQM EEAELHDKLF QLLETSKSLI VFDDIWKDED WDLIKPIFPP NKGWKVLLTS
QNESVAVRGD IKYLNFKPEC LAIEDSWTLF QRIAFPKKDA SESKVDEEME DMGKQMLKHC
GGLPLAIKVL GGLLAAKYTM HDWERLSVNI GSDIVGRTSS NNSSIYHVLS MSFEELPSYL
KHCFLYLAHF PEDHKINVEK LSYCWAAEGI STAEDYHNGE TIQDVGQSYL EELVRRNMII
WERDATASRF GTCHLHDMMR EVCLFKAKEE NFLQIAVKSV GVTSSSTGNS QSPCRSRRLV
YQCPTTLHVE RDINNPKLRS LVVLWHDLWV ENWKLLGTSF TRLKLLRVLD LFYVDFEGMK
LPFGIGNLIH LRYLSLQDAK VSHLPSSLGN LMLLIYLNLD VDTEFIFVPD VFMRMHELRY
LKLPLHMHKK TRLSLRNLVK LETLVYFSTW HSSSKDLCGM TRLMTLAIRL TRVTSTETLS
ASISGLRNLE YLYIVGTHSK KMREEGIVLD FIHLKHLLLD LYMPRQQHFP SRLTFVKLSE
CGLEEDPMPI LEKLLHLKGV ILLKGSYCGR RMVCSGGGFP QLKKLEIVGL NKWEEWLVEE
GSMPLLETLS ILDCEELKEI PDGLRFIYSL ELVMLGTRWK KKFSVGGEDY YKVQHIPSVE
FIGGYLK
