DRL8_ARATH
ID DRL8_ARATH Reviewed; 910 AA.
AC Q8W3K3; F4IBC7; O64974; Q9C645;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Putative disease resistance protein At1g58400;
GN OrderedLocusNames=At1g58400; ORFNames=F9K23.7, X7J.13;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kato A., Komeda Y.;
RT "Long repeat sequence within a genomic region located around the 100 map
RT unit of chromosome 1 in Arabidopsis thaliana.";
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 200-362.
RC STRAIN=cv. Columbia;
RX PubMed=9530866; DOI=10.1094/mpmi.1998.11.4.251;
RA Aarts M.G.M., te Lintel Hekkert B., Holub E.B., Beynon J.L., Stiekema W.J.,
RA Pereira A.;
RT "Identification of R-gene homologous DNA fragments genetically linked to
RT disease resistance loci in Arabidopsis thaliana.";
RL Mol. Plant Microbe Interact. 11:251-258(1998).
CC -!- FUNCTION: Potential disease resistance protein.
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG50637.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AEE33545.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
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DR EMBL; AC082643; AAG50637.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE33545.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; ANM60088.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60089.1; -; Genomic_DNA.
DR EMBL; AB077822; BAB83872.1; -; Genomic_DNA.
DR EMBL; AF039380; AAC14556.1; -; Genomic_DNA.
DR PIR; G96617; G96617.
DR RefSeq; NP_001319266.1; NM_001333831.1.
DR RefSeq; NP_001322397.1; NM_001333833.1.
DR RefSeq; NP_001322398.1; NM_001333832.1.
DR AlphaFoldDB; Q8W3K3; -.
DR SMR; Q8W3K3; -.
DR STRING; 3702.AT1G58400.1; -.
DR PaxDb; Q8W3K3; -.
DR PRIDE; Q8W3K3; -.
DR ProteomicsDB; 224349; -.
DR EnsemblPlants; AT1G58400.2; AT1G58400.2; AT1G58400.
DR EnsemblPlants; AT1G58400.3; AT1G58400.3; AT1G58400.
DR GeneID; 842209; -.
DR Gramene; AT1G58400.2; AT1G58400.2; AT1G58400.
DR Gramene; AT1G58400.3; AT1G58400.3; AT1G58400.
DR KEGG; ath:AT1G58400; -.
DR Araport; AT1G58400; -.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000837_25_4_1; -.
DR InParanoid; Q8W3K3; -.
DR OMA; RTELRMM; -.
DR OrthoDB; 992188at2759; -.
DR PhylomeDB; Q8W3K3; -.
DR PRO; PR:Q8W3K3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8W3K3; baseline and differential.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW Plant defense; Reference proteome; Repeat.
FT CHAIN 1..910
FT /note="Putative disease resistance protein At1g58400"
FT /id="PRO_0000212740"
FT DOMAIN 148..460
FT /note="NB-ARC"
FT REPEAT 580..604
FT /note="LRR 1"
FT REPEAT 605..628
FT /note="LRR 2"
FT COILED 15..57
FT /evidence="ECO:0000255"
FT BINDING 191..198
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT CONFLICT 265
FT /note="E -> G (in Ref. 4; AAC14556)"
FT /evidence="ECO:0000305"
FT CONFLICT 307
FT /note="A -> T (in Ref. 4; AAC14556)"
FT /evidence="ECO:0000305"
FT CONFLICT 320
FT /note="E -> G (in Ref. 4; AAC14556)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 910 AA; 105677 MW; 91A6E69ADFABBBD3 CRC64;
MVEAIVSFGV EKLWDRLTQE YEQFQGVEDR IAELKSNLNL LKSFLKDAEA KKNTSQMVRH
CVEEIKEIVY DTENMIETFI LKEAARKRSG IIRRITKLTC IKVHRWEFAS DIGGISKRIS
KVIQDMHSFG VQQMISDGSQ SSHLLQERER EMRQTFSRGY ESDFVGLEVN VKKLVGYLVE
EDDIQIVSVT GMGGLGKTTL ARQVFNHEDV KHQFDRLAWV CVSQEFTRKN VWQMILQNLT
SRETKDEILQ MEEAELHDEL FQLLETSKSL IVFDDIWKEE DWGLINPIFP PKKGWKVLIT
SRTETIAMHG NRRYVNFKPE CLTILESWIL FQRIAMPRVD ESEFKVDKEM EMMGKQMIKY
CGGLPLAVKV LGGLLAAKYT FHDWKRLSEN IGCHIVGRTD FSDGNNSSVY HVLSLSFEEL
PSYLKHCFLY LAHFPEDHNI KVEKLSYCWA AEGILEPRHY HGQTIRDVGE SYIEELVRRN
MVIAERDVTT LRFEACHLHD MMREVCLLKA KEENFVQIAS ILPPTANSQY PGTSRRFVSQ
NPTTLHVSRD INNPKLQSLL IVWENRRKSW KLLGSSFIRL ELLRVLDLYK AKFEGRNLPS
GIGKLIHLRY LNLDLARVSR LPSSLGNLRL LIYLDINVCT KSLFVPNCLM GMHELRYLRL
PFNTSKEIKL GLCNLVNLET LENFSTENSS LEDLRGMVSL RTLTIGLFKH ISKETLFASI
LGMRHLENLS IRTPDGSSKF KRIMEDGIVL DAIHLKQLNL RLYMPKLPDE QHFPSHLTSI
SLDGCCLVED PLPILEKLLE LKEVRLDFRA FCGKRMVSSD GGFPQLHRLY IWGLAEWEEW
IVEEGSMPRL HTLTIWNCQK LKQLPDGLRF IYSIKDLDMD KKWKEILSEG GEEYYKVQHI
PSVKFEKDYK
