DRL9_ARATH
ID DRL9_ARATH Reviewed; 1138 AA.
AC Q8W3K0; Q94A96;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Probable disease resistance protein At1g58602;
GN OrderedLocusNames=At1g58602; ORFNames=R18I.4;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. Columbia;
RA Kato A., Komeda Y.;
RT "Long repeat sequence within a genomic region located around the 100 map
RT unit of chromosome 1 in Arabidopsis thaliana.";
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-244.
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- FUNCTION: Potential disease resistance protein.
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
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DR EMBL; AB078516; BAB84011.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33556.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33557.1; -; Genomic_DNA.
DR EMBL; AY049262; AAK83604.1; -; mRNA.
DR RefSeq; NP_001077742.1; NM_001084273.3.
DR RefSeq; NP_683441.1; NM_148600.3.
DR AlphaFoldDB; Q8W3K0; -.
DR SMR; Q8W3K0; -.
DR BioGRID; 27445; 1.
DR STRING; 3702.AT1G58602.2; -.
DR PaxDb; Q8W3K0; -.
DR PRIDE; Q8W3K0; -.
DR ProteomicsDB; 224350; -.
DR EnsemblPlants; AT1G58602.1; AT1G58602.1; AT1G58602.
DR EnsemblPlants; AT1G58602.2; AT1G58602.2; AT1G58602.
DR GeneID; 842220; -.
DR Gramene; AT1G58602.1; AT1G58602.1; AT1G58602.
DR Gramene; AT1G58602.2; AT1G58602.2; AT1G58602.
DR KEGG; ath:AT1G58602; -.
DR Araport; AT1G58602; -.
DR TAIR; locus:504956186; AT1G58602.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000837_35_5_1; -.
DR InParanoid; Q8W3K0; -.
DR OMA; MTHERID; -.
DR OrthoDB; 164862at2759; -.
DR PhylomeDB; Q8W3K0; -.
DR PRO; PR:Q8W3K0; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8W3K0; baseline and differential.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW Plant defense; Reference proteome; Repeat.
FT CHAIN 1..1138
FT /note="Probable disease resistance protein At1g58602"
FT /id="PRO_0000212741"
FT DOMAIN 146..464
FT /note="NB-ARC"
FT REPEAT 581..605
FT /note="LRR 1"
FT REPEAT 606..631
FT /note="LRR 2"
FT REPEAT 681..705
FT /note="LRR 3"
FT REPEAT 774..797
FT /note="LRR 4"
FT REPEAT 798..825
FT /note="LRR 5"
FT REPEAT 847..871
FT /note="LRR 6"
FT REPEAT 893..918
FT /note="LRR 7"
FT REPEAT 940..963
FT /note="LRR 8"
FT REPEAT 1078..1103
FT /note="LRR 9"
FT COILED 25..52
FT /evidence="ECO:0000255"
FT BINDING 189..196
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1138 AA; 131655 MW; 13E94BE58A924207 CRC64;
MAGELVSFAV NKLWDLLSHE YTLFQGVEDQ VAELKSDLNL LKSFLKDADA KKHTSALVRY
CVEEIKDIVY DAEDVLETFV QKEKLGTTSG IRKHIKRLTC IVPDRREIAL YIGHVSKRIT
RVIRDMQSFG VQQMIVDDYM HPLRNREREI RRTFPKDNES GFVALEENVK KLVGYFVEED
NYQVVSITGM GGLGKTTLAR QVFNHDMVTK KFDKLAWVSV SQDFTLKNVW QNILGDLKPK
EEETKEEEKK ILEMTEYTLQ RELYQLLEMS KSLIVLDDIW KKEDWEVIKP IFPPTKGWKL
LLTSRNESIV APTNTKYFNF KPECLKTDDS WKLFQRIAFP INDASEFEID EEMEKLGEKM
IEHCGGLPLA IKVLGGMLAE KYTSHDWRRL SENIGSHLVG GRTNFNDDNN NSCNYVLSLS
FEELPSYLKH CFLYLAHFPE DYEIKVENLS YYWAAEEIFQ PRHYDGEIIR DVGDVYIEEL
VRRNMVISER DVKTSRFETC HLHDMMREVC LLKAKEENFL QITSNPPSTA NFQSTVTSRR
LVYQYPTTLH VEKDINNPKL RSLVVVTLGS WNMAGSSFTR LELLRVLDLV QAKLKGGKLA
SCIGKLIHLR YLSLEYAEVT HIPYSLGNLK LLIYLNLHIS LSSRSNFVPN VLMGMQELRY
LALPSLIERK TKLELSNLVK LETLENFSTK NSSLEDLRGM VRLRTLTIEL IEETSLETLA
ASIGGLKYLE KLEIDDLGSK MRTKEAGIVF DFVHLKRLRL ELYMPRLSKE QHFPSHLTTL
YLQHCRLEED PMPILEKLLQ LKELELGHKS FSGKKMVCSS CGFPQLQKLS ISGLKEWEDW
KVEESSMPLL LTLNIFDCRK LKQLPDEHLP SHLTAISLKK CGLEDPIPTL ERLVHLKELS
LSELCGRIMV CTGGGFPQLH KLDLSELDGL EEWIVEDGSM PRLHTLEIRR CLKLKKLPNG
FPQLQNLHLT EVEEWEEGMI VKQGSMPLLH TLYIWHCPKL PGEQHFPSHL TTVFLLGMYV
EEDPMRILEK LLHLKNVSLF QSFSGKRMVC SGGGFPQLQK LSIREIEWEE WIVEQGSMPL
LHTLYIGVCP NLKELPDGLR FIYSLKNLIV SKRWKKRLSE GGEDYYKVQH IPSVEFDD
