DRM1A_ORYSJ
ID DRM1A_ORYSJ Reviewed; 473 AA.
AC Q2RBJ4; A0A0P0XY10; D2KY68;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=DNA (cytosine-5)-methyltransferase DRM1A {ECO:0000305};
DE EC=2.1.1.37 {ECO:0000305};
DE AltName: Full=Protein DOMAINS REARRANGED METHYLASE 1A {ECO:0000305};
DE Short=OsDRM1A {ECO:0000303|PubMed:22380881};
GN Name=DRM1A {ECO:0000303|PubMed:22380881};
GN OrderedLocusNames=Os11g0109200 {ECO:0000312|EMBL:BAH95035.1},
GN LOC_Os11g01810 {ECO:0000312|EMBL:ABA91139.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG The rice chromosomes 11 and 12 sequencing consortia;
RT "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT genes and recent gene duplications.";
RL BMC Biol. 3:20-20(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 164-352.
RC STRAIN=cv. Nipponbare; TISSUE=Leaf blade;
RX PubMed=22380881; DOI=10.1111/j.1365-313x.2012.04974.x;
RA Moritoh S., Eun C.H., Ono A., Asao H., Okano Y., Yamaguchi K.,
RA Shimatani Z., Koizumi A., Terada R.;
RT "Targeted disruption of an orthologue of DOMAINS REARRANGED METHYLASE 2,
RT OsDRM2, impairs the growth of rice plants by abnormal DNA methylation.";
RL Plant J. 71:85-98(2012).
CC -!- FUNCTION: Involved in de novo DNA methylation. Involved in RNA-directed
CC DNA methylation (RdDM). {ECO:0000250|UniProtKB:Q10SU5}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-
CC methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU01017};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. DRM-methyltransferase family. {ECO:0000255|PROSITE-
CC ProRule:PRU01017}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAT12347.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DP000010; ABA91139.1; -; Genomic_DNA.
DR EMBL; AP008217; BAH95035.1; -; Genomic_DNA.
DR EMBL; AP014967; BAT12347.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB524356; BAI66066.1; -; mRNA.
DR AlphaFoldDB; Q2RBJ4; -.
DR SMR; Q2RBJ4; -.
DR STRING; 39947.Q2RBJ4; -.
DR PRIDE; Q2RBJ4; -.
DR eggNOG; ENOG502QVZV; Eukaryota.
DR InParanoid; Q2RBJ4; -.
DR Proteomes; UP000000763; Chromosome 11.
DR Proteomes; UP000059680; Chromosome 11.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006306; P:DNA methylation; IBA:GO_Central.
DR Gene3D; 3.40.50.150; -; 2.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR030380; SAM_MeTfrase_DRM.
DR Pfam; PF00145; DNA_methylase; 1.
DR SUPFAM; SSF53335; SSF53335; 2.
DR PROSITE; PS51680; SAM_MT_DRM; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Methyltransferase; Nucleus; Reference proteome; Repeat;
KW S-adenosyl-L-methionine; Transferase.
FT CHAIN 1..473
FT /note="DNA (cytosine-5)-methyltransferase DRM1A"
FT /id="PRO_0000438151"
FT DOMAIN 20..61
FT /note="UBA 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00212"
FT DOMAIN 120..140
FT /note="UBA 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00212"
FT DOMAIN 204..431
FT /note="SAM-dependent MTase DRM-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01017"
FT REGION 84..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..98
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..115
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 473 AA; 53163 MW; 398ADD21E49A8E3C CRC64;
MRIASSSGIL MDANGKANGS APSALVAYFL GMGFSREMVF RAIKEIGDTD SEQILELLLT
YQAIGSDPSV GNSSHSACDP QILEEEDEEE DVNWDEDDTV DNFDRATYSD GSGDEDFLQE
MSEKDEKIKS LVSMGFPEDE DTEFSSFGGR KKTKLIDGSK KKRERYRSRP QWNQVPFDGS
HEEPMPLPNS MVGFSLPNDG LRSVHRNLPD QALGPPFFYY ENVALAPKGV WTTISRFLYD
IYPEFVYSKY FCAAARKRGY IHNLPIKNRN YTRGVSRTAR YRALGNSFQV DTVAYHLSVL
RDIFPNGMNV LSLFSGIGGA EVALHRLGIC MKTVVLVEIS EVNMTLLRSW WDQTQTGTLI
EIADVQNLTA ERIELFIRRF GGFDLVIGGS PCNNLAGSNR YHRDGLEGKH SALFYHYYRI
LDSVKTIMAS IFGAKGKLFR HVRKALLLKQ SSSLTLKTEQ DPSNNSDKDS MDK
