ID   DRM1B_ORYSJ             Reviewed;         437 AA.
AC   Q2QYR5; A0A0P0Y6M9;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Probable inactive DNA (cytosine-5)-methyltransferase DRM1B {ECO:0000305};
DE   AltName: Full=Protein DOMAINS REARRANGED METHYLASE 1B {ECO:0000305};
GN   Name=DRM1B {ECO:0000305};
GN   OrderedLocusNames=Os12g0108900 {ECO:0000312|EMBL:BAF28973.1},
GN   LOC_Os12g01800 {ECO:0000312|EMBL:ABA96193.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG   The rice chromosomes 11 and 12 sequencing consortia;
RT   "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT   genes and recent gene duplications.";
RL   BMC Biol. 3:20-20(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
CC   -!- FUNCTION: Involved in de novo DNA methylation. Involved in RNA-directed
CC       DNA methylation (RdDM). {ECO:0000250|UniProtKB:Q10SU5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. DRM-methyltransferase family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01017}.
CC   -!- CAUTION: Lacks the conserved tripeptide Ser-Pro-Cys in position 405
CC       necessary for the methyltransferase activity in DRM protein (AC
CC       Q9M548).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAT15529.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; DP000011; ABA96193.1; -; Genomic_DNA.
DR   EMBL; AP008218; BAF28973.1; -; Genomic_DNA.
DR   EMBL; AP014968; BAT15529.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; Q2QYR5; -.
DR   SMR; Q2QYR5; -.
DR   STRING; 4530.OS12T0108900-00; -.
DR   PRIDE; Q2QYR5; -.
DR   eggNOG; ENOG502QVZV; Eukaryota.
DR   HOGENOM; CLU_006805_0_0_1; -.
DR   InParanoid; Q2QYR5; -.
DR   Proteomes; UP000000763; Chromosome 12.
DR   Proteomes; UP000059680; Chromosome 12.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006306; P:DNA methylation; IBA:GO_Central.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR030380; SAM_MeTfrase_DRM.
DR   InterPro; IPR015940; UBA.
DR   InterPro; IPR009060; UBA-like_sf.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS51680; SAM_MT_DRM; 1.
DR   PROSITE; PS50030; UBA; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Methyltransferase; Nucleus; Reference proteome; Repeat;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..437
FT                   /note="Probable inactive DNA (cytosine-5)-methyltransferase
FT                   DRM1B"
FT                   /id="PRO_0000438152"
FT   DOMAIN          20..60
FT                   /note="UBA 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00212"
FT   DOMAIN          120..164
FT                   /note="UBA 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00212"
FT   DOMAIN          243..437
FT                   /note="SAM-dependent MTase DRM-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01017"
SQ   SEQUENCE   437 AA;  49630 MW;  7B0F20640B525732 CRC64;
     MRIASSSGIL MDANGKANGS APSALVAYFL GMGFSREMVF RAIKEIGNDN NNTFPHLLQL
     LPFLSGDTDS EQILELLLTY QILEEEDEEE DVNWDEDDTV DNFDRATYSD GSGDEDFLQE
     MSEKDEKIKS LVSMGFPEDE AMRAITRCGL DASVDLLVES IYAPASAGNV YFTNLSDYED
     TEFSSFGGRK KTKLIDGTKK KRERYRSRPQ WNQVPFDGSH EEPMPLPNPM VGFSLPNDGL
     RSVHRNLPDH ALGPPFFYYE NVALAPKGVW TTISRFLYDI YPEFVDSKYF CAAARKRGYI
     HNLPIENRSP VLPIPPKTIS EAFPSTKMWW PSWDPRRQFN CLQTYVASAK HTERIRCALG
     RFGDALPPAV QKSVLEECRK WNLVWVGKNK VATLEPDEME FLLGYPRNHT RGVSRKRDIE
     LLGIHSKLIQ LHTTSLC