ID   DRMB_BACP9              Reviewed;         561 AA.
AC   P0DW06;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   03-AUG-2022, sequence version 1.
DT   03-AUG-2022, entry version 1.
DE   RecName: Full=DISARM protein DrmB {ECO:0000303|PubMed:29085076};
GN   Name=drmB {ECO:0000303|PubMed:29085076};
GN   OrderedLocusNames=BaLi_c08330 {ECO:0000312|EMBL:AGN35228.1};
OS   Bacillus paralicheniformis (strain ATCC 9945a / NCIMB 11709 / CD-2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=766760;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 9945a / NCIMB 11709 / CD-2;
RX   PubMed=23908277; DOI=10.1128/genomea.00525-13;
RA   Rachinger M., Volland S., Meinhardt F., Daniel R., Liesegang H.;
RT   "First Insights into the Completely Annotated Genome Sequence of Bacillus
RT   licheniformis Strain 9945A.";
RL   Genome Announc. 1:0-0(2013).
RN   [2]
RP   FUNCTION, DISRUPTION PHENOTYPE, AND EXPRESSION IN B.SUBTILIS.
RC   STRAIN=ATCC 9945a / NCIMB 11709 / CD-2;
RX   PubMed=29085076; DOI=10.1038/s41564-017-0051-0;
RA   Ofir G., Melamed S., Sberro H., Mukamel Z., Silverman S., Yaakov G.,
RA   Doron S., Sorek R.;
RT   "DISARM is a widespread bacterial defence system with broad anti-phage
RT   activities.";
RL   Nat. Microbiol. 3:90-98(2018).
CC   -!- FUNCTION: Component of antiviral defense system DISARM (defense island
CC       system associated with restriction-modification), composed of DrmE,
CC       DrmA, DrmB, DrmC and DrmMII. DISARM is probably a multi-gene
CC       restriction module, this subunit has an unknown function. Expression of
CC       DISARM in B.subtilis (strain BEST7003) confers resistance to phages Nf,
CC       phi29, phi105, phi3T, SPO1, SPR and SPP1. Protection is over 10(7)-fold
CC       against phi3T, 10(4)-10(5)-fold against Nf, phi29, phi105 and SPR, 100-
CC       fold against SPO1 and 10-fold against SPP1. DISARM does not interfere
CC       with phage adsorption, but instead interferes with (phi3T) DNA
CC       replication early in its cycle, preventing replication, circularization
CC       and lysogeny and probably causes phage DNA degradation (DNA is degraded
CC       in SPP1-infected cells). {ECO:0000269|PubMed:29085076}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: When this gene is missing the DISARM system does
CC       not confer Nf, phi3T or SPO1 resistance in B.subtilis.
CC       {ECO:0000269|PubMed:29085076}.
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DR   EMBL; CP005965; AGN35228.1; -; Genomic_DNA.
PE   4: Predicted;
KW   Antiviral defense; Cytoplasm; Restriction system.
FT   CHAIN           1..561
FT                   /note="DISARM protein DrmB"
FT                   /id="PRO_0000456309"
SQ   SEQUENCE   561 AA;  64343 MW;  82AC677A6DE14B66 CRC64;
     MDSVNDSLVI LDIKYWTNHN NKKIFDKNLM KFLKKDYFRK IPSTKHKDLP AIPFPNYHVC
     SNVKCSRLFD LRDNFVMSDY LKGGPKCPDC SRKSYPARFV VSCQENHLDD FPWRWWAHGK
     QDTECKGKLR LWSTGNTSSL DSLYVECECK KKKSLRGAMQ DSSFENYKCT GNHPHKLNEK
     SNCNEPVIPL QRGASNVYFP ALRSAIVIPS NASEDNNLDD FFTSVKEVIN TYADLIGENW
     HYKFYSDRLT GHSEFSDAED FIAKWTSYLN SNDSEEEIEY NQIKEAEYRA FTAFDRKVKM
     GDFEAEVETV PDDFQPYFNR IVKAHRLKEI LVLLGFMRND SPEPDVNEPK KIVWLESDGY
     ENWLPAIEVH GEGIFIEFNH TTISKWLEEN SELPKRSEKF SSLYASWIES KGWEVRDEKD
     IVYVMLHTFA HLLIKQLSLQ SGYSSVAIKE RIYCGKNMAG VLLYTGSTDQ EGSLGGLVEM
     GSIDKLRPLI VDALEEAIFC SNDPSCASLE PSEDNQLNGC ACFACSMVAE TSCETGNRLL
     DRSLLVKTID SKYSPFFKGL L