ID   DRN1_STREQ              Reviewed;         327 AA.
AC   P26295;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Deoxyribonuclease;
DE            Short=DNase;
DE            EC=3.1.21.1;
DE   AltName: Full=Streptodornase;
DE   Flags: Precursor;
GN   Name=sdc;
OS   Streptococcus dysgalactiae subsp. equisimilis (Streptococcus equisimilis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=119602;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=H46A;
RX   PubMed=1937032; DOI=10.1016/0378-1119(91)90574-u;
RA   Wolinowska R., Ceglowski P., Kok J., Venema G.;
RT   "Isolation, sequence and expression in Escherichia coli, Bacillus subtilis
RT   and Lactococcus lactis of the DNase (streptodornase)-encoding gene from
RT   Streptococcus equisimilis H46A.";
RL   Gene 106:115-119(1991).
CC   -!- FUNCTION: May have a role in S.equisimilis virulence.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-
CC         phosphooligonucleotide end-products.; EC=3.1.21.1;
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DR   EMBL; X17241; CAA35106.1; -; Genomic_DNA.
DR   PIR; JT0584; JT0584.
DR   AlphaFoldDB; P26295; -.
DR   SMR; P26295; -.
DR   GO; GO:0004530; F:deoxyribonuclease I activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   Gene3D; 3.40.570.10; -; 1.
DR   InterPro; IPR001604; DNA/RNA_non-sp_Endonuclease.
DR   InterPro; IPR044929; DNA/RNA_non-sp_Endonuclease_sf.
DR   InterPro; IPR044927; Endonuclea_NS_2.
DR   Pfam; PF13930; Endonuclea_NS_2; 1.
DR   SMART; SM00892; Endonuclease_NS; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Signal; Virulence.
FT   SIGNAL          1..24
FT                   /note="Or 35"
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..327
FT                   /note="Deoxyribonuclease"
FT                   /id="PRO_0000021119"
FT   REGION          299..327
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   327 AA;  36844 MW;  7529702FDF8E4AF7 CRC64;
     MSKKLRNFLV RIIVAAFASF AVMAIPPYHH NTVLAKTVSV NQTYGEYKDY YTVIGESNID
     QSAFPKIYKT TERVYKGQGT SEKRVTVSDV VYNPLDGYKR STGAYGVVTK DMIDMSKGYR
     EKWETNPEPS GWFRFYNRAD NEEISEKEYD SRRTKSYKVT NNVPVVLTTL KGKKYNSHLF
     VASHLFADSL GGKSIRKNAI TGTQMQNVGT RKGGMQYIEK KVLSHITKNP DVYVFYSAIP
     EYQGAELLAR SVLVSALSSD GVINETVRVF NTADGFNINY EKGGLLTESP VSEIDNIEDS
     TTDEIENSVD DSEEIVYNDT TTEEEEN