ID   DRNE_AERHY              Reviewed;         230 AA.
AC   P39658;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Extracellular deoxyribonuclease;
DE            Short=DNase;
DE            EC=3.1.21.-;
DE   Flags: Precursor;
GN   Name=dns;
OS   Aeromonas hydrophila.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=644;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CHC-1;
RX   PubMed=1452026; DOI=10.1016/0378-1119(92)90046-r;
RA   Chang M.C., Chang S.Y., Chen S.L., Chuang S.M.;
RT   "Cloning and expression in Escherichia coli of the gene encoding an
RT   extracellular deoxyribonuclease (DNase) from Aeromonas hydrophila.";
RL   Gene 122:175-180(1992).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the EndA/NucM nuclease family. {ECO:0000305}.
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DR   EMBL; M99491; AAA21942.1; -; Genomic_DNA.
DR   PIR; JC1483; JC1483.
DR   AlphaFoldDB; P39658; -.
DR   SMR; P39658; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   InterPro; IPR007346; Endonuclease-I.
DR   InterPro; IPR044925; His-Me_finger_sf.
DR   PANTHER; PTHR33607; PTHR33607; 1.
DR   Pfam; PF04231; Endonuclease_1; 1.
DR   SUPFAM; SSF54060; SSF54060; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..230
FT                   /note="Extracellular deoxyribonuclease"
FT                   /id="PRO_0000007830"
SQ   SEQUENCE   230 AA;  26699 MW;  D6C60274CFAE7E29 CRC64;
     MFRPLLSLCL ALLVSAPAHA DNIQTFRAAK QDLNKLYQSH PVTFYCGCNI KFSGKKMAPD
     WESCGYLPGK QAERASRIEW EHVVPAWEFG HQLQCWQDGG RKNCGKSDEF NRMEGDMHNL
     FPAIGEVNGD RANFRFSDWN GKPNQYGKCQ MLVDFKERQV QPPKGPVRGQ IARAYLYMSQ
     QYGLRLAAQQ RKLYEAWDRQ YPADRWECER NRRIGKLQGN TNPFIEKQCQ