ID   DRNF_AERHY              Reviewed;         237 AA.
AC   Q44064;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Periplasmic deoxyribonuclease;
DE            Short=DNase;
DE            EC=3.1.21.-;
DE   Flags: Precursor;
GN   Name=dnsH;
OS   Aeromonas hydrophila.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=644;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=JMP636;
RX   PubMed=10220879; DOI=10.1111/j.1574-6968.1999.tb13482.x;
RA   Dodd H.N., Pemberton J.M.;
RT   "The gene encoding a periplasmic deoxyribonuclease from Aeromonas
RT   hydrophila.";
RL   FEMS Microbiol. Lett. 173:41-46(1999).
CC   -!- FUNCTION: Endonuclease which is capable of degrading plasmid DNA.
CC   -!- SUBCELLULAR LOCATION: Periplasm.
CC   -!- SIMILARITY: Belongs to the EndA/NucM nuclease family. {ECO:0000305}.
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DR   EMBL; L78266; AAB01347.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q44064; -.
DR   SMR; Q44064; -.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   InterPro; IPR007346; Endonuclease-I.
DR   InterPro; IPR044925; His-Me_finger_sf.
DR   PANTHER; PTHR33607; PTHR33607; 1.
DR   Pfam; PF04231; Endonuclease_1; 1.
DR   SUPFAM; SSF54060; SSF54060; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Periplasm; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..237
FT                   /note="Periplasmic deoxyribonuclease"
FT                   /id="PRO_0000007831"
SQ   SEQUENCE   237 AA;  27377 MW;  754CE0EE5A6D9D78 CRC64;
     MSRPSRVLGL PLLSLGLTLL VSTPLQAQEA QTFRAVKQDL VKLYQSHPST FYCGCNIKFS
     GKKMAPDWES CGYLPRKQAN RAARIEWEHV VPAWEFGHQL QCWQEGGRKN CGKSAEFNKM
     EGDMHNLFPA IGEVNGDRAN YRFSDWNGKP NQYGKCQMLV DFKEQRVQPP KGPVRGQIAR
     AYLYMGEQYG LRLAAQQRKL FEAWDRQYPA DRWECERNRR IGKLQGNTNP FIEKQCQ