ID   DROS_DROSI              Reviewed;          64 AA.
AC   Q6XMH8;
DT   13-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Drosocin;
DE   Flags: Precursor;
GN   Name=Dro;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12716986; DOI=10.1093/molbev/msg109;
RA   Lazzaro B.P., Clark A.G.;
RT   "Molecular population genetics of inducible antibacterial peptide genes in
RT   Drosophila melanogaster.";
RL   Mol. Biol. Evol. 20:914-923(2003).
CC   -!- FUNCTION: Antibacterial peptide with strong anti-Gram-negative bacteria
CC       activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the drosocin family. {ECO:0000305}.
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DR   EMBL; AY224618; AAO72477.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6XMH8; -.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:EnsemblMetazoa.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; ISS:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:EnsemblMetazoa.
DR   GO; GO:0002213; P:defense response to insect; IEA:EnsemblMetazoa.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0006964; P:positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria; ISS:UniProtKB.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Cleavage on pair of basic residues;
KW   Glycoprotein; Immunity; Innate immunity; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..21
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000004961"
FT   PEPTIDE         22..40
FT                   /note="Drosocin"
FT                   /id="PRO_0000004962"
FT   PROPEP          43..64
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000004963"
FT   CARBOHYD        28
FT                   /note="O-linked (GalNAc...) serine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        32
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   64 AA;  7069 MW;  51CE9C9A42FCAD10 CRC64;
     MKFTIVFLLL ACVFAMAVAT PGKPRPYSPR PTSHPRPIRV RREALAIEDH LAQAAIRPPP
     ILPA