DRP4C_ARATH
ID DRP4C_ARATH Reviewed; 669 AA.
AC Q9ZP55;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Dynamin-related protein 4C;
GN Name=DRP4C; OrderedLocusNames=At1g60500; ORFNames=F8A5.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14750516; DOI=10.1023/b:plan.0000007000.29697.81;
RA Hong Z., Bednarek S.Y., Blumwald E., Hwang I., Jurgens G., Menzel D.,
RA Osteryoung K.W., Raikhel N.V., Shinozaki K., Tsutsumi N., Verma D.P.S.;
RT "A unified nomenclature for Arabidopsis dynamin-related large GTPases based
RT on homology and possible functions.";
RL Plant Mol. Biol. 53:261-265(2003).
CC -!- FUNCTION: Putative microtubule-associated force-producing protein, able
CC to bind and hydrolyze GTP. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton
CC {ECO:0000250}. Note=Microtubule-associated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Dynamin/Fzo/YdjA family. {ECO:0000255|PROSITE-
CC ProRule:PRU01055}.
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DR EMBL; AC002292; AAB71966.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33694.1; -; Genomic_DNA.
DR PIR; C96630; C96630.
DR RefSeq; NP_176252.1; NM_104736.2.
DR AlphaFoldDB; Q9ZP55; -.
DR SMR; Q9ZP55; -.
DR STRING; 3702.AT1G60500.1; -.
DR PaxDb; Q9ZP55; -.
DR PRIDE; Q9ZP55; -.
DR ProteomicsDB; 224369; -.
DR EnsemblPlants; AT1G60500.1; AT1G60500.1; AT1G60500.
DR GeneID; 842345; -.
DR Gramene; AT1G60500.1; AT1G60500.1; AT1G60500.
DR KEGG; ath:AT1G60500; -.
DR Araport; AT1G60500; -.
DR TAIR; locus:2036566; AT1G60500.
DR eggNOG; KOG0446; Eukaryota.
DR HOGENOM; CLU_008964_8_3_1; -.
DR InParanoid; Q9ZP55; -.
DR OMA; MTEILEM; -.
DR OrthoDB; 494748at2759; -.
DR PhylomeDB; Q9ZP55; -.
DR PRO; PR:Q9ZP55; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9ZP55; baseline and differential.
DR Genevisible; Q9ZP55; AT.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR CDD; cd08771; DLP_1; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR003130; GED.
DR InterPro; IPR020850; GED_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11566; PTHR11566; 1.
DR Pfam; PF01031; Dynamin_M; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF02212; GED; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SMART; SM00302; GED; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
DR PROSITE; PS51388; GED; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; GTP-binding; Hydrolase; Microtubule;
KW Motor protein; Nucleotide-binding; Reference proteome.
FT CHAIN 1..669
FT /note="Dynamin-related protein 4C"
FT /id="PRO_0000415907"
FT DOMAIN 62..323
FT /note="Dynamin-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT DOMAIN 575..669
FT /note="GED"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00720"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 72..79
FT /note="G1 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 97..99
FT /note="G2 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 171..174
FT /note="G3 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 240..243
FT /note="G4 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 273
FT /note="G5 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT BINDING 72..79
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 171..175
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 240..243
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
SQ SEQUENCE 669 AA; 74598 MW; 4FC05B6CCF39848E CRC64;
MVKKKVATKK NSPSLAIAKK KSRSNKDVVS VEAPIISSYN DRIRPLLDTV DRLRNLNVMR
EGIHLPTIVV VGDQSSGKSS VLESLAGISL PRGQGICTRV PLVMRLQRSS SPEPEIWLEY
NDKVVPTDEE HIAEAIRAAT DVIAGSGKGV SDAPLTLHVK KAGVPDLTMV DLPGITRVPV
NGQPENIYEQ ISGMIMEYIE PQESIILNVL SATVDFTTCE SIRMSRKVDK TGQRTLAVVT
KADMAPEGLL QKVTADDVSI VLGYVCVRNR IGEETYEEAR MQEELLFRTH PVLSLIDEDI
VGIPVLAQKL MLIQSSMIAR CLPKIVSKIN QKLDTAVLEL NKLPMVMAST GEALMALMDI
IGSAKESLLR ILVQGDFSEY PDDQNMHCTA RLADMLSQFS DSLQAKPKEV AEFLMDEIKI
LDECKCVGLP NFIPRSAFLA ILSQHVDGIQ DKPVEFINKI WDYIEDVLSS VTAKRSDNFP
QIQSSIKRAG RNLISKIKEQ SVNRVMEIVE MEKLTDYTCN PEYMTSWTQK TSAQESFIDA
VVKNENIPDY FSVTGFGNVK ISHLRKYHAH LLIPAFDMKM RITSYWKIVL RRIVDNLALY
LQLSVKSLVN TRFQKEIVAE MVDPRDGGGV EKMLEESPLV ASKREKLQNS IKLLKESKDA
VAAIVDQNC
