ID   DRRC_MYCTO              Reviewed;         276 AA.
AC   P9WG20; L0TBB3; P96207; Q7D6E6;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Probable doxorubicin resistance ABC transporter permease protein DrrC;
GN   Name=drrC; OrderedLocusNames=MT3008;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Probably part of the ABC transporter complex DrrABC involved
CC       in doxorubicin resistance. Probably responsible for the translocation
CC       of the substrate across the membrane (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (DrrA) and
CC       two transmembrane proteins (DrrB and DrrC). {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ABC-2 integral membrane protein family.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK47335.1; -; Genomic_DNA.
DR   PIR; F70984; F70984.
DR   RefSeq; WP_003414851.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WG20; -.
DR   EnsemblBacteria; AAK47335; AAK47335; MT3008.
DR   GeneID; 45426926; -.
DR   KEGG; mtc:MT3008; -.
DR   PATRIC; fig|83331.31.peg.3248; -.
DR   HOGENOM; CLU_039483_2_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR   GO; GO:0043215; P:daunorubicin transport; IEA:InterPro.
DR   GO; GO:1900753; P:doxorubicin transport; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR013525; ABC_2_trans.
DR   InterPro; IPR000412; ABC_2_transport.
DR   InterPro; IPR004377; ABC_transpt_DrrB/DrrC.
DR   InterPro; IPR005943; Daunbcin-R_C.
DR   Pfam; PF01061; ABC2_membrane; 1.
DR   PIRSF; PIRSF006648; DrrB; 1.
DR   TIGRFAMs; TIGR01248; drrC; 1.
DR   TIGRFAMs; TIGR00025; Mtu_efflux; 1.
DR   PROSITE; PS51012; ABC_TM2; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..276
FT                   /note="Probable doxorubicin resistance ABC transporter
FT                   permease protein DrrC"
FT                   /id="PRO_0000428438"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          46..273
FT                   /note="ABC transmembrane type-2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00442"
SQ   SEQUENCE   276 AA;  29593 MW;  FEED68CA5EFA0090 CRC64;
     MITTTSQEIE LAPTRLPGSQ NAARLFVAQT LLQTNRLLTR WARDYITVIG AIVLPILFMV
     VLNIVLGNLA YVVTHDSGLY SIVPLIALGA AITGSTFVAI DLMRERSFGL LARLWVLPVH
     RASGLISRIL ANAIRTLVTT LVMLGTGVVL GFRFRQGLIP SLMWISVPVI LGIAIAAMVT
     TVALYTAQTV VVEGVELVQA IAIFFSTGLV PLNSYPGWIQ PFVAHQPVSY AIAAMRGFAM
     GGPVLSPMIG MLVWTAGICV VCAVPLAIGY RRASTH