DRRC_MYCTU
ID DRRC_MYCTU Reviewed; 276 AA.
AC P9WG21; L0TBB3; P96207; Q7D6E6;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 38.
DE RecName: Full=Probable doxorubicin resistance ABC transporter permease protein DrrC;
GN Name=drrC; OrderedLocusNames=Rv2938;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA Raman K., Yeturu K., Chandra N.;
RT "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT through an interactome, reactome and genome-scale structural analysis.";
RL BMC Syst. Biol. 2:109-109(2008).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- FUNCTION: Probably part of the ABC transporter complex DrrABC involved
CC in doxorubicin resistance. Probably responsible for the translocation
CC of the substrate across the membrane.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (DrrA) and
CC two transmembrane proteins (DrrB and DrrC). {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC -!- SIMILARITY: Belongs to the ABC-2 integral membrane protein family.
CC {ECO:0000305}.
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DR EMBL; AL123456; CCP45741.1; -; Genomic_DNA.
DR PIR; F70984; F70984.
DR RefSeq; NP_217454.1; NC_000962.3.
DR RefSeq; WP_003414851.1; NZ_NVQJ01000015.1.
DR AlphaFoldDB; P9WG21; -.
DR STRING; 83332.Rv2938; -.
DR PaxDb; P9WG21; -.
DR DNASU; 888491; -.
DR GeneID; 45426926; -.
DR GeneID; 888491; -.
DR KEGG; mtu:Rv2938; -.
DR TubercuList; Rv2938; -.
DR eggNOG; COG0842; Bacteria.
DR OMA; QPFVEHQ; -.
DR PhylomeDB; P9WG21; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR GO; GO:0051701; P:biological process involved in interaction with host; IMP:MTBBASE.
DR GO; GO:0043215; P:daunorubicin transport; IEA:InterPro.
DR GO; GO:1900753; P:doxorubicin transport; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR GO; GO:0052572; P:response to host immune response; IMP:MTBBASE.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR000412; ABC_2_transport.
DR InterPro; IPR004377; ABC_transpt_DrrB/DrrC.
DR InterPro; IPR005943; Daunbcin-R_C.
DR Pfam; PF01061; ABC2_membrane; 1.
DR PIRSF; PIRSF006648; DrrB; 1.
DR TIGRFAMs; TIGR01248; drrC; 1.
DR TIGRFAMs; TIGR00025; Mtu_efflux; 1.
DR PROSITE; PS51012; ABC_TM2; 1.
PE 1: Evidence at protein level;
KW Antibiotic resistance; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..276
FT /note="Probable doxorubicin resistance ABC transporter
FT permease protein DrrC"
FT /id="PRO_0000393227"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 46..273
FT /note="ABC transmembrane type-2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00442"
SQ SEQUENCE 276 AA; 29593 MW; FEED68CA5EFA0090 CRC64;
MITTTSQEIE LAPTRLPGSQ NAARLFVAQT LLQTNRLLTR WARDYITVIG AIVLPILFMV
VLNIVLGNLA YVVTHDSGLY SIVPLIALGA AITGSTFVAI DLMRERSFGL LARLWVLPVH
RASGLISRIL ANAIRTLVTT LVMLGTGVVL GFRFRQGLIP SLMWISVPVI LGIAIAAMVT
TVALYTAQTV VVEGVELVQA IAIFFSTGLV PLNSYPGWIQ PFVAHQPVSY AIAAMRGFAM
GGPVLSPMIG MLVWTAGICV VCAVPLAIGY RRASTH
