ID   DRRP_DEIRA              Reviewed;         574 AA.
AC   Q9RTJ3;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Desiccation/radiation resistance protein DR_1769;
DE   Flags: Precursor;
GN   OrderedLocusNames=DR_1769;
OS   Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG
OS   4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae;
OC   Deinococcus.
OX   NCBI_TaxID=243230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC   9279 / R1 / VKM B-1422;
RX   PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA   White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA   Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA   Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA   Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA   Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA   Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA   Fraser C.M.;
RT   "Genome sequence of the radioresistant bacterium Deinococcus radiodurans
RT   R1.";
RL   Science 286:1571-1577(1999).
RN   [2]
RP   FUNCTION IN RESISTANCE, DOMAIN, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC   9279 / R1 / VKM B-1422;
RX   PubMed=23794625; DOI=10.1128/jb.00418-13;
RA   Rajpurohit Y.S., Misra H.S.;
RT   "DR1769, a protein with N-terminal beta propeller repeats and a low-
RT   complexity hydrophilic tail, plays a role in desiccation tolerance of
RT   Deinococcus radiodurans.";
RL   J. Bacteriol. 195:3888-3896(2013).
CC   -!- FUNCTION: Plays an important role in resistance to desiccation and
CC       radiation, maybe by protecting genome integrity under extreme
CC       conditions. {ECO:0000269|PubMed:23794625}.
CC   -!- DOMAIN: Contains an N-terminal PQQ binding domain and a C-terminal
CC       disorganized low-complexity (LC) hydrophilic region.
CC       {ECO:0000269|PubMed:23794625}.
CC   -!- DISRUPTION PHENOTYPE: Mutant is sensitive to gamma radiation and
CC       hypersensitive to desiccation. It shows delayed DNA double-strand break
CC       repair and delayed recovery of desiccated nucleoid.
CC       {ECO:0000269|PubMed:23794625}.
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DR   EMBL; AE000513; AAF11323.1; -; Genomic_DNA.
DR   PIR; F75356; F75356.
DR   RefSeq; NP_295492.1; NC_001263.1.
DR   RefSeq; WP_010888404.1; NZ_CP015081.1.
DR   AlphaFoldDB; Q9RTJ3; -.
DR   SMR; Q9RTJ3; -.
DR   STRING; 243230.DR_1769; -.
DR   EnsemblBacteria; AAF11323; AAF11323; DR_1769.
DR   KEGG; dra:DR_1769; -.
DR   PATRIC; fig|243230.17.peg.1981; -.
DR   eggNOG; COG1520; Bacteria.
DR   HOGENOM; CLU_473061_0_0_0; -.
DR   InParanoid; Q9RTJ3; -.
DR   OMA; IYFGAQD; -.
DR   OrthoDB; 1377603at2; -.
DR   Proteomes; UP000002524; Chromosome I.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0030729; F:acetoacetate-CoA ligase activity; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR   InterPro; IPR002372; PQQ_repeat.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF13360; PQQ_2; 2.
DR   SMART; SM00564; PQQ; 7.
DR   SUPFAM; SSF50998; SSF50998; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Signal.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000255"
FT   CHAIN           34..574
FT                   /note="Desiccation/radiation resistance protein DR_1769"
FT                   /id="PRO_0000429794"
FT   REGION          400..461
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        400..423
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        424..461
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   574 AA;  58433 MW;  6B45667FF96C7C7C CRC64;
     MPDPAARRFS LPPFPLAALA LSVALLGAPA SLAQTAAPAP APAQTPAAAS RAAAPRVSWT
     KPLKVSSPVS IGPRGELTYV GNDSRVHRTD ASGKELWSFA LGDIGRAQPV LTPDGGVITA
     AYDDTVYALS PAGQLTWKAK LDGDVFASPA LRPDGSVVVA TAGGTVYALS SSGQTLWSYK
     VGAPVFSSPA VAADGTIYFG AQNGRLHALS PEGRLTWTYA ARSSVFSSPA LDAEGNLYFG
     SGDRSIYSLS PAGTLRWVQP TGLFVNASPI VTRAGLVVVG SYDGQLYALN TNGQVAWTYA
     AGAAIAAPAA ELSDGSVVVG DLNGTLHAVT PTGQALWTLP GGAKIDTGAA VSDQGTLYFA
     VDGGNLNAVE NLRPLATGPW PTFRASPLGW GRSATAAELT AQTQARQAAA AASTSQQPRL
     PTLAQAPAPT PAPAQTTPRP QPTPAQPATP AAPVPPVASP APATARLTPQ VIGGVIYLPL
     SPIAAGLGYQ VQAGSPTRAL LVAGSQRLTV PVRAVGGQSL IALRFVTGLP GVSVERQAGT
     LTLRREGLSA ALPLDLAQLL PWAPQPEFPG VVRR