DRS12_PHYTB
ID DRS12_PHYTB Reviewed; 29 AA.
AC C0HLC1;
DT 10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2018, sequence version 1.
DT 25-MAY-2022, entry version 5.
DE RecName: Full=Dermaseptin-1.2TR {ECO:0000303|PubMed:29980138};
OS Phyllomedusa trinitatis (Trinidad leaf frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC Phyllomedusa.
OX NCBI_TaxID=332092 {ECO:0000303|PubMed:29980138};
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, SUBCELLULAR LOCATION, MASS SPECTROMETRY, AND AMIDATION AT
RP VAL-29.
RC TISSUE=Skin secretion {ECO:0000303|PubMed:29980138};
RX PubMed=29980138; DOI=10.1016/j.cbd.2018.06.006;
RA Mechkarska M., Coquet L., Leprince J., Auguste R.J., Jouenne T.,
RA Mangoni M.L., Conlon J.M.;
RT "Peptidomic analysis of the host-defense peptides in skin secretions of the
RT Trinidadian leaf frog Phyllomedusa trinitatis (Phyllomedusidae).";
RL Comp. Biochem. Physiol. 28:72-79(2018).
CC -!- FUNCTION: Has antimicrobial activity. {ECO:0000250|UniProtKB:P84921}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29980138}.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC {ECO:0000305|PubMed:29980138}.
CC -!- MASS SPECTROMETRY: Mass=2953.6; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:29980138};
CC -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC Dermaseptin subfamily. {ECO:0000305}.
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DR AlphaFoldDB; C0HLC1; -.
DR SMR; C0HLC1; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR InterPro; IPR022731; Dermaseptin.
DR Pfam; PF12121; DD_K; 1.
PE 1: Evidence at protein level;
KW Amidation; Amphibian defense peptide; Antimicrobial;
KW Direct protein sequencing; Secreted.
FT PEPTIDE 1..29
FT /note="Dermaseptin-1.2TR"
FT /evidence="ECO:0000269|PubMed:29980138"
FT /id="PRO_0000445210"
FT MOD_RES 29
FT /note="Valine amide"
FT /evidence="ECO:0000269|PubMed:29980138"
SQ SEQUENCE 29 AA; 2955 MW; CEA47A1A1BD880F3 CRC64;
GLWSKIKETG KEAAKAAGKA ALDKIAEAV