ID   DRS2_PHYSA              Reviewed;          34 AA.
AC   P80278;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Dermaseptin-S2 {ECO:0000303|PubMed:18644413};
DE            Short=DRS-S2 {ECO:0000303|PubMed:18644413};
DE   AltName: Full=Dermaseptin II {ECO:0000303|PubMed:8306981};
DE            Short=DS II {ECO:0000303|PubMed:8306981};
DE   AltName: Full=Dermaseptin-2;
DE            Short=DS2;
OS   Phyllomedusa sauvagei (Sauvage's leaf frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Phyllomedusa.
OX   NCBI_TaxID=8395;
RN   [1]
RP   PROTEIN SEQUENCE, AND SUBCELLULAR LOCATION.
RC   TISSUE=Skin secretion;
RX   PubMed=8306981; DOI=10.1111/j.1432-1033.1994.tb19924.x;
RA   Mor A., Nicolas P.;
RT   "Isolation and structure of novel defensive peptides from frog skin.";
RL   Eur. J. Biochem. 219:145-154(1994).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=18644413; DOI=10.1016/j.peptides.2008.06.017;
RA   Amiche M., Ladram A., Nicolas P.;
RT   "A consistent nomenclature of antimicrobial peptides isolated from frogs of
RT   the subfamily Phyllomedusinae.";
RL   Peptides 29:2074-2082(2008).
CC   -!- FUNCTION: Potent antimicrobial peptide with activity against bacteria
CC       and protozoa (By similarity). Also has activity against fungi
CC       (PubMed:8306981). Probably acts by disturbing membrane functions with
CC       its amphipathic structure (Probable). {ECO:0000250|UniProtKB:P24302,
CC       ECO:0000269|PubMed:8306981, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8306981}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000305|PubMed:8306981}.
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Dermaseptin subfamily. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=The antimicrobial peptide database;
CC       URL="https://wangapd3.com/database/query_output.php?ID=0158";
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DR   AlphaFoldDB; P80278; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR022731; Dermaseptin.
DR   Pfam; PF12121; DD_K; 1.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Fungicide; Secreted.
FT   PEPTIDE         1..34
FT                   /note="Dermaseptin-S2"
FT                   /evidence="ECO:0000269|PubMed:8306981"
FT                   /id="PRO_0000044733"
SQ   SEQUENCE   34 AA;  3473 MW;  C528CBCD5BAC239E CRC64;
     ALWFTMLKKL GTMALHAGKA ALGAAANTIS QGTQ