ID   DRS2_PITAZ              Reviewed;          28 AA.
AC   P84937;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 20.
DE   RecName: Full=Dermaseptin-H2;
DE   AltName: Full=Dermaseptin-like peptide 2;
DE            Short=DMS2;
OS   Pithecopus azureus (Orange-legged monkey tree frog) (Phyllomedusa azurea).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Pithecopus.
OX   NCBI_TaxID=2034991;
RN   [1]
RP   PROTEIN SEQUENCE, AND SUBCELLULAR LOCATION.
RC   TISSUE=Skin secretion;
RA   Thompson A.H.;
RT   "A genomic/proteomic approach to isolating and identifying bioactive
RT   peptides from the skin secretions of Phyllomedusa hypochondrialis azurea.";
RL   Thesis (2006), University of Ulster Coleraine, United Kingdom.
CC   -!- FUNCTION: Possesses a potent antimicrobial activity against Gram-
CC       positive and Gram-negative bacteria. Probably acts by disturbing
CC       membrane functions with its amphipathic structure (By similarity).
CC       {ECO:0000250|UniProtKB:P81487}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands. {ECO:0000305|Ref.1}.
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Dermaseptin subfamily. {ECO:0000255}.
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DR   AlphaFoldDB; P84937; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR022731; Dermaseptin.
DR   Pfam; PF12121; DD_K; 1.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Secreted.
FT   PEPTIDE         1..28
FT                   /note="Dermaseptin-H2"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000250577"
SQ   SEQUENCE   28 AA;  2739 MW;  231583E3315A372F CRC64;
     GLWSKIKDVA AAAGKAALGA VNEALGEQ