ID   DRS4_PHYDS              Reviewed;          30 AA.
AC   P83641;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=Dermaseptin-DI4 {ECO:0000303|PubMed:18644413};
DE            Short=DRS-DI4 {ECO:0000303|PubMed:18644413};
DE   AltName: Full=Dermadistinctin-Q1 {ECO:0000303|PubMed:10477123};
DE            Short=DD Q1 {ECO:0000303|PubMed:10477123};
OS   Phyllomedusa distincta (Monkey frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Phyllomedusa.
OX   NCBI_TaxID=164618 {ECO:0000305};
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, CIRCULAR DICHROISM ANALYSIS, AND SYNTHESIS.
RC   TISSUE=Skin secretion;
RX   PubMed=10477123; DOI=10.1016/s0196-9781(99)00050-9;
RA   Batista C.V.F., da Silva L.R., Sebben A., Scaloni A., Ferrara L.,
RA   Paiva G.R., Olamendi-Portugal T., Possani L.D., Bloch C. Jr.;
RT   "Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta.";
RL   Peptides 20:679-686(1999).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=18644413; DOI=10.1016/j.peptides.2008.06.017;
RA   Amiche M., Ladram A., Nicolas P.;
RT   "A consistent nomenclature of antimicrobial peptides isolated from frogs of
RT   the subfamily Phyllomedusinae.";
RL   Peptides 29:2074-2082(2008).
CC   -!- FUNCTION: Antibacterial activity against Gram-positive bacteria
CC       S.aureus and E.faecalis, and Gram-negative bacteria P.aeruginosa and
CC       E.coli. {ECO:0000269|PubMed:10477123}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10477123}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:10477123}.
CC   -!- MASS SPECTROMETRY: Mass=2781.4; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:10477123};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Dermaseptin subfamily. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=The antimicrobial peptide database;
CC       URL="https://wangapd3.com/database/query_output.php?ID=0961";
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DR   AlphaFoldDB; P83641; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR022731; Dermaseptin.
DR   Pfam; PF12121; DD_K; 1.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Secreted.
FT   PEPTIDE         1..30
FT                   /note="Dermaseptin-DI4"
FT                   /id="PRO_0000043638"
SQ   SEQUENCE   30 AA;  2997 MW;  FD5F190C3DCBBEB5 CRC64;
     ALWKNMLKGI GKLAGQAALG AVKTLVGAES