ID   DRS5_PHYBI              Reviewed;          26 AA.
AC   P81487;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Dermaseptin-B5 {ECO:0000303|PubMed:18644413, ECO:0000303|PubMed:9614066};
DE            Short=DRS-B5 {ECO:0000303|PubMed:18644413, ECO:0000303|PubMed:9614066};
DE   AltName: Full=Dermaseptin-BV;
OS   Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Phyllomedusa.
OX   NCBI_TaxID=8393;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND AMIDATION AT VAL-26.
RC   TISSUE=Skin secretion;
RX   PubMed=9614066; DOI=10.1074/jbc.273.24.14690;
RA   Charpentier S., Amiche M., Mester J., Vouille V., Le Caer J.-P.,
RA   Nicolas P., Delfour A.;
RT   "Structure, synthesis, and molecular cloning of dermaseptins B, a family of
RT   skin peptide antibiotics.";
RL   J. Biol. Chem. 273:14690-14697(1998).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=18644413; DOI=10.1016/j.peptides.2008.06.017;
RA   Amiche M., Ladram A., Nicolas P.;
RT   "A consistent nomenclature of antimicrobial peptides isolated from frogs of
RT   the subfamily Phyllomedusinae.";
RL   Peptides 29:2074-2082(2008).
CC   -!- FUNCTION: Possesses a potent antimicrobial activity against Gram-
CC       positive and Gram-negative bacteria. Probably acts by disturbing
CC       membrane functions with its amphipathic structure.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9614066}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000305|PubMed:9614066}.
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Dermaseptin subfamily. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=The antimicrobial peptide database;
CC       URL="https://wangapd3.com/database/query_output.php?ID=0162";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P81487; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR022731; Dermaseptin.
DR   Pfam; PF12121; DD_K; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Secreted.
FT   PEPTIDE         1..26
FT                   /note="Dermaseptin-B5"
FT                   /evidence="ECO:0000269|PubMed:9614066"
FT                   /id="PRO_0000043636"
FT   MOD_RES         26
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000269|PubMed:9614066"
SQ   SEQUENCE   26 AA;  2704 MW;  6CD339B33A2A7334 CRC64;
     GLWNKIKEAA SKAAGKAALG FVNEMV