ID   DRS5_PITHY              Reviewed;          34 AA.
AC   P84598;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=Dermaseptin-H5 {ECO:0000303|PubMed:18644413};
DE            Short=DRS-H5 {ECO:0000303|PubMed:18644413};
DE   AltName: Full=DShypo 03 {ECO:0000303|PubMed:16844081};
OS   Pithecopus hypochondrialis (Orange-legged leaf frog) (Phyllomedusa
OS   hypochondrialis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Pithecopus.
OX   NCBI_TaxID=317381;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Skin secretion;
RX   PubMed=16844081; DOI=10.1016/j.bbrc.2006.06.168;
RA   Brand G.D., Leite J.R.S.A., de Sa Mandel S.M., Mesquita D.A., Silva L.P.,
RA   Prates M.V., Barbosa E.A., Vinecky F., Martins G.R., Galasso J.H.,
RA   Kuckelhaus S.A.S., Sampaio R.N.R., Furtado J.R. Jr., Andrade A.C.,
RA   Bloch C. Jr.;
RT   "Novel dermaseptins from Phyllomedusa hypochondrialis (Amphibia).";
RL   Biochem. Biophys. Res. Commun. 347:739-746(2006).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=18644413; DOI=10.1016/j.peptides.2008.06.017;
RA   Amiche M., Ladram A., Nicolas P.;
RT   "A consistent nomenclature of antimicrobial peptides isolated from frogs of
RT   the subfamily Phyllomedusinae.";
RL   Peptides 29:2074-2082(2008).
CC   -!- FUNCTION: Has antimicrobial activity. {ECO:0000250|UniProtKB:P80282}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16844081}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:16844081}.
CC   -!- MASS SPECTROMETRY: Mass=3352.96; Mass_error=0.1; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:16844081};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Dermaseptin subfamily. {ECO:0000255}.
CC   -!- WEB RESOURCE: Name=The antimicrobial peptide database;
CC       URL="https://wangapd3.com/database/query_output.php?ID=0946";
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DR   AlphaFoldDB; P84598; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   InterPro; IPR022731; Dermaseptin.
DR   Pfam; PF12121; DD_K; 1.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Antimicrobial; Direct protein sequencing;
KW   Secreted.
FT   PEPTIDE         1..34
FT                   /note="Dermaseptin-H5"
FT                   /evidence="ECO:0000269|PubMed:16844081"
FT                   /id="PRO_0000248495"
SQ   SEQUENCE   34 AA;  3354 MW;  E4F14ECD49BF8540 CRC64;
     ALWKDVLKKI GTVALHAGKA AFGAAADTIS QGGS