ID   DRS6_PITHY              Reviewed;          33 AA.
AC   P84599;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 24.
DE   RecName: Full=Dermaseptin-H6 {ECO:0000303|PubMed:18644413};
DE            Short=DRS-H6 {ECO:0000303|PubMed:18644413};
DE   AltName: Full=DShypo 04 {ECO:0000303|PubMed:16844081};
OS   Pithecopus hypochondrialis (Orange-legged leaf frog) (Phyllomedusa
OS   hypochondrialis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Pithecopus.
OX   NCBI_TaxID=317381;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AND AMIDATION AT LEU-33.
RC   TISSUE=Skin secretion;
RX   PubMed=16844081; DOI=10.1016/j.bbrc.2006.06.168;
RA   Brand G.D., Leite J.R.S.A., de Sa Mandel S.M., Mesquita D.A., Silva L.P.,
RA   Prates M.V., Barbosa E.A., Vinecky F., Martins G.R., Galasso J.H.,
RA   Kuckelhaus S.A.S., Sampaio R.N.R., Furtado J.R. Jr., Andrade A.C.,
RA   Bloch C. Jr.;
RT   "Novel dermaseptins from Phyllomedusa hypochondrialis (Amphibia).";
RL   Biochem. Biophys. Res. Commun. 347:739-746(2006).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=18644413; DOI=10.1016/j.peptides.2008.06.017;
RA   Amiche M., Ladram A., Nicolas P.;
RT   "A consistent nomenclature of antimicrobial peptides isolated from frogs of
RT   the subfamily Phyllomedusinae.";
RL   Peptides 29:2074-2082(2008).
CC   -!- FUNCTION: Has antimicrobial activity. {ECO:0000250|UniProtKB:P83637}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16844081}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:16844081}.
CC   -!- MASS SPECTROMETRY: Mass=3236.84; Mass_error=0.1; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:16844081};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Dermaseptin subfamily. {ECO:0000255}.
CC   -!- WEB RESOURCE: Name=The antimicrobial peptide database;
CC       URL="https://wangapd3.com/database/query_output.php?ID=0947";
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DR   AlphaFoldDB; P84599; -.
DR   SMR; P84599; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   InterPro; IPR022731; Dermaseptin.
DR   Pfam; PF12121; DD_K; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Antimicrobial;
KW   Direct protein sequencing; Secreted.
FT   PEPTIDE         1..33
FT                   /note="Dermaseptin-H6"
FT                   /id="PRO_0000248496"
FT   MOD_RES         33
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:16844081"
SQ   SEQUENCE   33 AA;  3239 MW;  27B08086C8459A47 CRC64;
     GLWSTIKQKG KEAAIAAAKA AGKAVLNAAS EAL