ID   DRS7B_BOVIN             Reviewed;         325 AA.
AC   Q3T0R4;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Dehydrogenase/reductase SDR family member 7B {ECO:0000250|UniProtKB:Q6IAN0};
DE            EC=1.1.-.- {ECO:0000305};
DE   AltName: Full=Short-chain dehydrogenase/reductase family 32C member 1 {ECO:0000250|UniProtKB:Q6IAN0};
DE            Short=Protein SDR32C1 {ECO:0000250|UniProtKB:Q6IAN0};
GN   Name=DHRS7B; Synonyms=SDR32C1 {ECO:0000250|UniProtKB:Q6IAN0};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative oxidoreductase. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q5RJY4}; Single-pass type II membrane protein
CC       {ECO:0000250|UniProtKB:Q5RJY4}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; BC102290; AAI02291.1; -; mRNA.
DR   RefSeq; NP_001030420.1; NM_001035343.2.
DR   AlphaFoldDB; Q3T0R4; -.
DR   SMR; Q3T0R4; -.
DR   STRING; 9913.ENSBTAP00000013968; -.
DR   PaxDb; Q3T0R4; -.
DR   PRIDE; Q3T0R4; -.
DR   GeneID; 522283; -.
DR   KEGG; bta:522283; -.
DR   CTD; 25979; -.
DR   eggNOG; KOG1205; Eukaryota.
DR   InParanoid; Q3T0R4; -.
DR   OrthoDB; 1313182at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; NAD; NADP; Oxidoreductase;
KW   Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..325
FT                   /note="Dehydrogenase/reductase SDR family member 7B"
FT                   /id="PRO_0000312104"
FT   TOPO_DOM        1..17
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        18..38
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        39..325
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        207
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         62
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         64
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         194
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         207
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         211
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         242
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
SQ   SEQUENCE   325 AA;  35032 MW;  2720AADCFCFA35E1 CRC64;
     MVSAATRKSL LRARVMDFIT STAILPLLLG CVGLFSLFKL LQWLRMRAYV RNAVVVITGA
     TSGLGRECAR VFHAAGARLV LCGRNAEALE ELSQELAASR APGVQTHKPC TVTFDLADPG
     AIAGAASEIL QCFGHVDVLI NNAGISYRGA IVDTSPDVDK RVMETNYFGP VALTKALLPA
     MIRRRQGHVV AISSIQGKIS LPFRSAYAAS KHATQAFFDC LRAEVEQHDI EVTVISPGYI
     HTNLSLNAVT ADGSKYGVMD ETTAQGRSPV QVAQDILAAL GKKKKDVVLA DPMPSLAVYL
     RTLAPGLFFR LMASRARKER KSKHS