ID   DRS7B_DANRE             Reviewed;         309 AA.
AC   Q566S6;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Dehydrogenase/reductase SDR family member 7B {ECO:0000250|UniProtKB:Q6IAN0};
DE            EC=1.1.-.- {ECO:0000305};
DE   AltName: Full=Short-chain dehydrogenase/reductase family 32C member 1 {ECO:0000250|UniProtKB:Q6IAN0};
DE            Short=Protein SDR32C1;
GN   Name=dhrs7b; Synonyms=sdr32c1 {ECO:0000250|UniProtKB:Q6IAN0};
GN   ORFNames=zgc:112518;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative oxidoreductase. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q5RJY4}; Single-pass type II membrane protein
CC       {ECO:0000250|UniProtKB:Q5RJY4}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; BC093357; AAH93357.1; -; mRNA.
DR   RefSeq; NP_001017758.1; NM_001017758.1.
DR   AlphaFoldDB; Q566S6; -.
DR   SMR; Q566S6; -.
DR   STRING; 7955.ENSDARP00000122514; -.
DR   PaxDb; Q566S6; -.
DR   PeptideAtlas; Q566S6; -.
DR   GeneID; 550454; -.
DR   KEGG; dre:550454; -.
DR   CTD; 25979; -.
DR   ZFIN; ZDB-GENE-050417-277; dhrs7b.
DR   eggNOG; KOG1205; Eukaryota.
DR   InParanoid; Q566S6; -.
DR   PhylomeDB; Q566S6; -.
DR   Reactome; R-DRE-75896; Plasmalogen biosynthesis.
DR   PRO; PR:Q566S6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; NAD; NADP; Oxidoreductase;
KW   Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..309
FT                   /note="Dehydrogenase/reductase SDR family member 7B"
FT                   /id="PRO_0000312109"
FT   TOPO_DOM        1..5
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        6..26
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        27..271
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        192
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         47
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         49
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         179
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         192
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         196
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         227
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
SQ   SEQUENCE   309 AA;  33348 MW;  C3ECF08BE075F58D CRC64;
     MERALGVGIG PLAAGTVGLL ILLKVIQRLR RRPNIQDKVV VITGASSGLG KECARVFHAA
     GARLILCGRD QRRLQEVVEE LGNKTYGKTK TYTPCTVTFD LSNTSVVCSA AAEILKRHGH
     VDVLINIAGV SYRGNILDTH VSVQREVMET NYFGPVALTQ AILPSMVDRG SGHIVVISSV
     QGKISIPYRS AYAASKHAMQ AYYDCLRAEV DSLGLHVSVL SPGYVRTNMS INAVTGDGSK
     YGVMDRTTAT GADPVDVAKD ILKAVCQKKK DVVMAGLGPT TAIYLRTLWP ALYFRVMASR
     ARKQTGKEE