DRS7B_PONAB
ID DRS7B_PONAB Reviewed; 325 AA.
AC Q5R6U1; Q5RAR4;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Dehydrogenase/reductase SDR family member 7B {ECO:0000250|UniProtKB:Q6IAN0};
DE EC=1.1.-.- {ECO:0000305};
DE AltName: Full=Short-chain dehydrogenase/reductase family 32C member 1 {ECO:0000250|UniProtKB:Q6IAN0};
DE Short=Protein SDR32C1;
GN Name=DHRS7B; Synonyms=SDR32C1 {ECO:0000250|UniProtKB:Q6IAN0};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Putative oxidoreductase. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q5RJY4}; Single-pass type II membrane protein
CC {ECO:0000250|UniProtKB:Q5RJY4}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5R6U1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5R6U1-2; Sequence=VSP_029699;
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAH92519.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; CR858948; CAH91146.1; -; mRNA.
DR EMBL; CR860393; CAH92519.1; ALT_FRAME; mRNA.
DR RefSeq; NP_001127381.1; NM_001133909.1.
DR RefSeq; NP_001128865.1; NM_001135393.1.
DR AlphaFoldDB; Q5R6U1; -.
DR SMR; Q5R6U1; -.
DR STRING; 9601.ENSPPYP00000009077; -.
DR GeneID; 100174447; -.
DR GeneID; 100189790; -.
DR KEGG; pon:100174447; -.
DR CTD; 25979; -.
DR eggNOG; KOG1205; Eukaryota.
DR InParanoid; Q5R6U1; -.
DR OrthoDB; 1313182at2759; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Endoplasmic reticulum; Membrane; NAD; NADP;
KW Oxidoreductase; Reference proteome; Signal-anchor; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..325
FT /note="Dehydrogenase/reductase SDR family member 7B"
FT /id="PRO_0000312107"
FT TOPO_DOM 1..17
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..325
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT ACT_SITE 207
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT BINDING 62
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250|UniProtKB:Q99714"
FT BINDING 64
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250|UniProtKB:Q99714"
FT BINDING 194
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:Q99714"
FT BINDING 207
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250|UniProtKB:Q99714"
FT BINDING 211
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250|UniProtKB:Q99714"
FT BINDING 242
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250|UniProtKB:Q99714"
FT VAR_SEQ 1..15
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_029699"
FT CONFLICT 122
FT /note="I -> V (in Ref. 1; CAH91146)"
FT /evidence="ECO:0000305"
FT CONFLICT 177
FT /note="L -> F (in Ref. 1; CAH91146)"
FT /evidence="ECO:0000305"
FT CONFLICT 182
FT /note="I -> T (in Ref. 1; CAH91146)"
FT /evidence="ECO:0000305"
FT CONFLICT 249
FT /note="V -> I (in Ref. 1; CAH91146)"
FT /evidence="ECO:0000305"
FT CONFLICT 255
FT /note="R -> S (in Ref. 1; CAH92519)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 325 AA; 35133 MW; BEAB0C9A709060BD CRC64;
MVSLATRKSL PKVKAMDFIT STAILPLLFS CLGVFGLFRL LQWVRGKAYL RNAVVVITGA
TSGLGKECAK VFYAAGAKLV LCGRNGGALE ELIRELTASH ATKVQTHKPY LVTFDLTDSG
AIVAAAAEIL QCFGYVDILV NNAGISYRGT IMDTTVDVDK RVMETNYFGP VALTKALLPS
MIKRRQGHIV AISSIQGKIS IPFRSAYAAS KHATQAFFDC LRAEMEQYEI EVTVISPGYI
HTNLSVNAVT ADGSRYGVMD TTTAQGRSPV EVAQDVLAAV GKKKKDVILA DLLPSLAVYL
RTLAPGLFFS LMASRARKER KSKNS
