ID   DRS7B_XENLA             Reviewed;         323 AA.
AC   Q0IH28;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Dehydrogenase/reductase SDR family member 7B {ECO:0000250|UniProtKB:Q6IAN0};
DE            EC=1.1.-.- {ECO:0000305};
DE   AltName: Full=Short-chain dehydrogenase/reductase family 32C member 1 {ECO:0000250|UniProtKB:Q6IAN0};
DE            Short=Protein SDR32C1;
GN   Name=dhrs7b; Synonyms=sdr32c1 {ECO:0000250|UniProtKB:Q6IAN0};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative oxidoreductase. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q5RJY4}; Single-pass type II membrane protein
CC       {ECO:0000250|UniProtKB:Q5RJY4}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; BC123346; AAI23347.1; -; mRNA.
DR   RefSeq; NP_001090401.1; NM_001096932.1.
DR   AlphaFoldDB; Q0IH28; -.
DR   SMR; Q0IH28; -.
DR   DNASU; 779313; -.
DR   GeneID; 779313; -.
DR   KEGG; xla:779313; -.
DR   CTD; 779313; -.
DR   Xenbase; XB-GENE-946478; dhrs7b.L.
DR   OrthoDB; 1313182at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 779313; Expressed in muscle tissue and 20 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; NAD; NADP; Oxidoreductase;
KW   Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..323
FT                   /note="Dehydrogenase/reductase SDR family member 7B"
FT                   /id="PRO_0000312110"
FT   TOPO_DOM        1..4
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        5..25
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        26..272
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        191
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         46
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         48
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         178
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         191
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         195
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         226
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
SQ   SEQUENCE   323 AA;  35153 MW;  607EEECF0DAD8956 CRC64;
     MDLTSWAIFP LLLASIGVYG LYKLLQKLRS GAYLQAAVVV ITGATSGLGK ECAKVFYAAG
     SHLVLCGRDE ERLKDLVQEL NNMRLKSTQL HKPHMVIFDL SDVEAVNTAA KEILHLAGRV
     DILINNAGIS YRGTILDTKV SVDRMVMDTN YFGPVALTKA LLPSMIKNRR GHVVVISSVQ
     GKISIPFRSA YSASKHATQA FFDCLRAEMS PYDIDVTVVN PGYIKTNLSL NAVTGDGSGY
     GVMDKNTADG RTPEEVAQTV LRAVGERRKE LLVAGLVPTL AVYLRTLAPT LFFSIMSARA
     KKRTKAKGFI TNSNLKAKIT VCI