ID   DRS7B_XENTR             Reviewed;         309 AA.
AC   Q0VFE7;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Dehydrogenase/reductase SDR family member 7B {ECO:0000250|UniProtKB:Q6IAN0};
DE            EC=1.1.-.- {ECO:0000305};
DE   AltName: Full=Short-chain dehydrogenase/reductase family 32C member 1 {ECO:0000250|UniProtKB:Q6IAN0};
DE            Short=Protein SDR32C1 {ECO:0000250|UniProtKB:Q6IAN0};
GN   Name=dhrs7b; Synonyms=sdr32c1 {ECO:0000250|UniProtKB:Q6IAN0};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative oxidoreductase. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q5RJY4}; Single-pass type II membrane protein
CC       {ECO:0000250|UniProtKB:Q5RJY4}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; BC118856; AAI18857.1; -; mRNA.
DR   RefSeq; NP_001072246.1; NM_001078778.1.
DR   RefSeq; XP_012825989.1; XM_012970535.2.
DR   RefSeq; XP_012825990.1; XM_012970536.2.
DR   AlphaFoldDB; Q0VFE7; -.
DR   SMR; Q0VFE7; -.
DR   STRING; 8364.ENSXETP00000013330; -.
DR   PaxDb; Q0VFE7; -.
DR   DNASU; 779695; -.
DR   Ensembl; ENSXETT00000013330; ENSXETP00000013330; ENSXETG00000006052.
DR   GeneID; 779695; -.
DR   KEGG; xtr:779695; -.
DR   CTD; 25979; -.
DR   Xenbase; XB-GENE-946473; dhrs7b.
DR   eggNOG; KOG1205; Eukaryota.
DR   HOGENOM; CLU_010194_2_1_1; -.
DR   InParanoid; Q0VFE7; -.
DR   OrthoDB; 1313182at2759; -.
DR   Reactome; R-XTR-75896; Plasmalogen biosynthesis.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000006052; Expressed in skeletal muscle tissue and 13 other tissues.
DR   ExpressionAtlas; Q0VFE7; baseline and differential.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; NAD; NADP; Oxidoreductase;
KW   Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..309
FT                   /note="Dehydrogenase/reductase SDR family member 7B"
FT                   /id="PRO_0000312111"
FT   TOPO_DOM        1..4
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        5..25
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        26..272
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        191
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         46
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         48
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         178
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         191
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         195
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         226
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
SQ   SEQUENCE   309 AA;  33818 MW;  1635C2FAB8A12406 CRC64;
     MDLTTWAIFP LLLGSIGVYS LYKLLQRLRS GAYLQDAVVV ITGATSGLGR ECAKVFYAAG
     TRLVLCGRSE EGLKNLVQEL SQMRIKSAQL HKPHMVIFDL SDVEAVNSAA NEILHLTGRV
     DILINNAGIS YRGTILDTKV SVDRMVMDTN YFGPVALTKA LIPSMIKNRR GHIVVISSVQ
     GKISIPFRSA YSASKHATQA FFDCLRAEMS PYEIDVTVVN PGYIKTNLSL NAVTGDGSNY
     GVMDNNTAEG RTPEEVAQTV LRAVGERRKE LLVAGLVPTL AVYLRTLAPT IFFSFMAARA
     KKERKLKDS